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Abstract：
When tetracyclines were introduced in the 1940s, these antibiotics offered a broad spectrum of activity against multiple types of pathogens. However, their utility waned after the selection of tetracycline resistance in the pathogens against which they were effective. Omadacycline is a semisynthetic aminomethylcycline antibacterial derived from the tetracycline class of antibiotics that is unaffected by these resistance mechanisms. It has an appropriate spectrum of activity for community-acquired infections, including those caused by many resistant organisms. Omadacycline offers a well-tolerated treatment for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Omadacycline has minimal known drug-drug interactions, and should be administered in a fasting state, avoiding dairy and cation-containing products for at least 4 hours after dosing. It does not require dose adjustments for sex, age, or hepatic or renal impairment, and has a safety profile similar to that of other oral tetracyclines. Because omadacycline can be administered effectively orally, it can help reduce hospitalization costs associated with intravenous antibiotic administration. This special supplement to Clinical Infectious Diseases offers an in-depth examination of omadacycline development, including discussions of pharmacokinetic and pharmacodynamic trials, spectrum of activity and preclinical data, early clinical trials, phase III clinical trials, and an integrated safety summary.
摘要：
当四环素在1940年代被引入时，这些抗生素提供了针对多种病原体的广谱活性。然而,在有效的病原体中选择四环素抗性后，它们的效用减弱。Omadacycline是一种半合成的氨基甲基环素抗菌药物，源自四环素类抗生素，不受这些耐药机制的影响。它对社区获得性感染有适当的活动范围，包括由许多抗性生物引起的。Omadacycline为急性细菌性皮肤和皮肤结构感染以及社区获得性细菌性肺炎提供良好的耐受性治疗。Omadacycline具有最小的已知药物相互作用，应该在禁食状态下给药，在给药后至少4小时内避免使用乳制品和含阳离子的产品。它不需要性别的剂量调整，年龄,或肝或肾损害，并且具有与其他口服四环素相似的安全性。因为奥马环素可以有效地口服给药，它可以帮助减少与静脉注射抗生素相关的住院费用。这种临床传染病的特殊补充提供了对omadacycline发展的深入检查，包括药代动力学和药效学试验的讨论，活动谱和临床前数据，早期临床试验,III期临床试验，和一个综合的安全总结。
