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Abstract：
Cache Valley virus (CVV) is a mosquito-borne RNA virus detected throughout North America, Central America and parts of South America. A limited number of human case reports have described severe illness. CVV infection has been associated with outbreaks of congenital defects in small ruminants in Canada and the United States. A scoping review was conducted to identify, characterize and summarize research on CVV, and to identify research gaps. A structured search was conducted in eight electronic databases, with additional search verification and grey literature investigation. All captured studies were independently appraised by two reviewers for relevance and data characterization. The review captured 143 relevant studies investigating CVV epidemiology (n = 104), pathogenesis (n = 37), viral characteristics (n = 24), transmission (n = 14), diagnostic test performance (n = 8) and mitigation strategies (n = 2). Evidence of CVV infection was found in mosquito studies (n = 47), and serological evidence of exposure was demonstrated in animals (n = 41), as well as human (n = 20) studies. In sheep, five outbreaks of birth defects following asymptomatic dam CVV infection during the first 50 days of pregnancy were reported. Only six human cases of CVV-associated illness were captured, with case symptoms described as initially non-specific, progressing to more severe clinical signs (e.g., meningitis). No research was identified investigating treatment, societal knowledge and risk perception, economic burden or predictive models related to the impact of climate change on CVV. CVV circulates in mosquito and animal species across a large area of the Americas. Small ruminants are the only animals in which CVV-associated clinical disease has been extensively studied. It is likely that human cases are under-reported or misdiagnosed. Future research should focus on the impact of CVV infection in human and animal populations.
摘要：
CacheValley病毒（CVV）是在整个北美检测到的蚊子传播的RNA病毒，中美洲和南美洲部分地区。有限数量的人类病例报告描述了严重的疾病。在加拿大和美国，CVV感染与小反刍动物先天性缺陷的爆发有关。进行了范围审查，以确定，对CVV的研究进行了表征和总结，并找出研究差距。在八个电子数据库中进行了结构化搜索，进行额外的搜索验证和灰色文献调查。所有捕获的研究均由两名审阅者独立评估相关性和数据表征。这篇综述收集了143项调查CVV流行病学的相关研究(n=104)，发病机制（n=37），病毒特征（n=24），传输（n=14），诊断测试性能(n=8)和缓解策略(n=2)。在蚊子研究中发现了CVV感染的证据（n=47），在动物中证明了暴露的血清学证据（n=41），以及人类（n=20）研究。在羊，据报道,在怀孕的前50天,无症状的大坝CVV感染后,有5次出生缺陷暴发.仅捕获了6例与CVV相关的人类病例，病例症状最初被描述为非特异性，进展到更严重的临床体征(例如，脑膜炎）。没有确定研究治疗方法，社会知识和风险感知，与气候变化对CVV影响相关的经济负担或预测模型。CVV在美洲大部分地区的蚊子和动物物种中传播。小反刍动物是唯一对CVV相关临床疾病进行广泛研究的动物。很可能人类病例报告不足或误诊。未来的研究应该集中在CVV感染对人类和动物种群的影响上。
