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Abstract：
Allergy risk has become a significant public health issue with increasing prevalence. Exclusive breastfeeding is recommended for the first six months of life, but this recommendation is poorly adhered to in many parts of the world, including the Middle-East region, putting infants at risk of developing allergic sensitization and disorders. When breastfeeding is not possible or not adequate, a partially hydrolyzed whey formula (pHF-W) has shown proven benefits of preventing allergy, mainly atopic eczema, in children with a genetic risk. Therefore, besides stimulating breastfeeding, early identification of infants at risk for developing atopic disease and replacing commonly used formula based on intact cow milk protein (CMP) with a clinically proven pHF-W formula is of paramount importance for allergy prevention. If the child is affected by cow\'s milk protein allergy (CMPA), expert guidelines recommend extensively hydrolyzed formula (eHF), or an amino acid formula (AAF) in case of severe symptoms. The Middle-East region has a unique practice of utilizing pHF-W as a step-down between eHF or AAF and intact CMP, which could be of benefit. The region is very heterogeneous with different levels of clinical practice, and as allergic disorders may be seen by healthcare professionals of different specialties with different levels of expertise, there is a great variability in preventive and treatment approaches within the region itself. During a consensus meeting, a new approach was discussed and unanimously approved by all participants, introducing the use of pHF-W in the therapeutic management of CMPA. This novel approach could be of worldwide benefit.
摘要：
随着患病率的增加，过敏风险已成为重要的公共卫生问题。建议在生命的前六个月进行纯母乳喂养，但是这个建议在世界许多地方都没有得到遵守，包括中东地区,使婴儿有发生过敏性致敏和疾病的风险。当母乳喂养不可能或不充分时，部分水解乳清配方（pHF-W）已证明有预防过敏的好处，主要是特应性湿疹，有遗传风险的儿童。因此,除了刺激母乳喂养，早期识别有发生特应性疾病风险的婴儿,并用经临床证实的pHF-W配方代替基于完整牛乳蛋白(CMP)的常用配方,对于预防过敏至关重要.如果孩子受到牛奶蛋白过敏（CMPA）的影响，专家指南推荐广泛水解配方（eHF），或氨基酸配方（AAF）在严重症状的情况下。中东地区有一种独特的做法，即利用pHF-W作为eHF或AAF与完整的CMP之间的降压，这可能是有益的。该地区具有不同的临床实践水平，由于过敏性疾病可能会被具有不同专业知识水平的不同专业的医疗保健专业人员看到，该地区本身的预防和治疗方法存在很大差异。在一次共识会议上，所有与会者都讨论并一致批准了一种新方法，介绍pHF-W在CMPA治疗管理中的应用。这种新颖的方法可能会在全球范围内受益。
