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Abstract：
We present a rare case of Acute Interstitial Nephritis (AIN) that occurred following a re-trial of clozapine in a 56-year-old lady with schizoaffective disorder. On initial trial of clozapine, this patient felt generally unwell with respiratory symptoms. Her inflammatory markers were raised and her renal function showed a mild, transient deterioration which normalised on the day of cessation of clozapine. Two years later, clozapine was re-trialled due the refractory nature of her psychiatric symptoms. She subsequently developed renal failure and AIN was confirmed by renal biopsy. Renal function improved after cessation of clozapine; however, she never fully regained normal renal function.
摘要：
我们介绍了一例罕见的急性间质性肾炎（AIN）病例，该病例是在一名56岁患有分裂情感障碍的女性中重新试验氯氮平后发生的。在最初的氯氮平试验中，该患者一般感觉不适，有呼吸道症状。她的炎症标志物升高，肾功能显示轻度，在停止氯氮平当天正常化的短暂恶化。两年后,氯氮平由于其精神症状的难治性而被重新试用。她随后出现肾衰竭，肾活检证实AIN。停用氯氮平后肾功能改善；然而，她没有完全恢复正常的肾功能.
