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Abstract：
The control of chitosan/silver nanoparticle composite microsphere (CAgMs) size is crucial for tuning its function. In the current work, monodisperse organically-modified CAgMs with controllable size were synthesized using a two-step method. The fine-tuning of the microsphere size was confirmed by many reaction parameters while the cross-linking agent was the key research object. Through physical and thermodynamic analysis, we found the cross-linking agent-induced smaller size, higher silver concentration, more heightened glass transition temperature and stronger hydrogen bond network. The as-prepared microspheres exhibited strong bacteriostasis and fresh-keeping function depending on cross-linking agent concentration. The phenomenon is believed to be derived from the difference in microorganism adsorption and killing ability from induced varying specific surface area and encapsulated silver content. Our current work highlights the size-controllable preparation of CAgMs, and based on our findings, small size CAgMs can be a promising candidate in the field of antibacterial and fruit preservation applications.
摘要：
壳聚糖/银纳米粒子复合微球(CAgMs)尺寸的控制对于调节其功能至关重要。在目前的工作中,使用两步法合成了具有可控尺寸的单分散有机改性CAgM。微球尺寸的微调得到了许多反应参数的证实，而交联剂是关键的研究对象。通过物理和热力学分析,我们发现交联剂诱导的尺寸较小，较高的银浓度，更高的玻璃化转变温度和更强的氢键网络。根据交联剂浓度的不同，所制备的微球具有很强的抑菌和保鲜功能。这种现象被认为是由微生物吸附和杀灭能力的差异引起的，该差异来自诱导的变化的比表面积和包封的银含量。我们目前的工作强调了CAGM的大小可控制备，根据我们的发现,小尺寸CAgMs可以在抗菌和水果保存应用领域是一个有前途的候选人。
