关键词: ALK inhibitor Anti-proliferation activity NSCLC Structure modification
Mesh : Adenocarcinoma of Lung / drug therapy Anaplastic Lymphoma Kinase / antagonists & inhibitors chemistry Animals Antineoplastic Agents / chemical synthesis pharmacology therapeutic use toxicity Binding Sites Cell Line, Tumor Cell Proliferation / drug effects Drug Stability Female Fibroblasts / drug effects Humans Lung Neoplasms / drug therapy Mice, Inbred BALB C Microsomes, Liver / metabolism Molecular Docking Simulation Molecular Structure Phenylurea Compounds / chemical synthesis pharmacology therapeutic use toxicity Protein Kinase Inhibitors / chemical synthesis pharmacology therapeutic use toxicity Pyridines / chemical synthesis pharmacology therapeutic use toxicity Pyrimidines / chemical synthesis pharmacology therapeutic use toxicity Structure-Activity Relationship Xenograft Model Antitumor Assays
来 源:
DOI:10.1016/j.ejmech.2019.05.060
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