PDF(Sci-hub)
Abstract：
The X-ray repair cross-complementing group 3 (XRCC3) is an efficient component of homologous recombination and is required for the preservation of chromosomal integrity in mammalian cells. The association between Thr241Met single-nucleotide polymorphism (SNP) in this gene and susceptibility to breast cancer has been assessed in several studies. Yet, reports are controversial. The present meta-analysis has been designed to identify whether this SNP is associated with susceptibility to breast cancer.
We performed a systematic review and meta-analysis for retrieving the case-control studies on the associations between T241 M SNP and the risk of breast cancer. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to verify the association in dominant, recessive, and homozygote inheritance models.
We included 55 studies containing 30,966 sporadic breast cancer cases, 1174 familial breast cancer cases and 32,890 controls in the meta-analysis. In crude analyses, no association was detected between the mentioned SNP and breast cancer risk in recessive, homozygote or dominant models. However, ethnic based analysis showed that in sporadic breast cancer, the SNP was associated with breast cancer risk in Arab populations in homozygous (OR (95% CI) = 3.649 (2.029-6.563), p = 0.0001) and recessive models (OR (95% CI) = 4.092 (1.806-9.271), p = 0.001). The association was significant in Asian population in dominant model (OR (95% CI) = 1.296, p = 0.029). However, the associations was significant in familial breast cancer in mixed ethnic-based subgroup in homozygote and recessive models (OR (95% CI) = 0.451 (0.309-0.659), p = 0.0001, OR (95% CI) = 0.462 (0.298-0.716), p = 0.001 respectively).
Taken together, our results in a large sample of both sporadic and familial cases of breast cancer showed insignificant role of Thr241Met in the pathogenesis of this type of malignancy. Such results were more conclusive in sporadic cases. In familial cases, future studies are needed to verify our results.
We performed a systematic review and meta-analysis for retrieving the case-control studies on the associations between T241 M SNP and the risk of breast cancer. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to verify the association in dominant, recessive, and homozygote inheritance models.
We included 55 studies containing 30,966 sporadic breast cancer cases, 1174 familial breast cancer cases and 32,890 controls in the meta-analysis. In crude analyses, no association was detected between the mentioned SNP and breast cancer risk in recessive, homozygote or dominant models. However, ethnic based analysis showed that in sporadic breast cancer, the SNP was associated with breast cancer risk in Arab populations in homozygous (OR (95% CI) = 3.649 (2.029-6.563), p = 0.0001) and recessive models (OR (95% CI) = 4.092 (1.806-9.271), p = 0.001). The association was significant in Asian population in dominant model (OR (95% CI) = 1.296, p = 0.029). However, the associations was significant in familial breast cancer in mixed ethnic-based subgroup in homozygote and recessive models (OR (95% CI) = 0.451 (0.309-0.659), p = 0.0001, OR (95% CI) = 0.462 (0.298-0.716), p = 0.001 respectively).
Taken together, our results in a large sample of both sporadic and familial cases of breast cancer showed insignificant role of Thr241Met in the pathogenesis of this type of malignancy. Such results were more conclusive in sporadic cases. In familial cases, future studies are needed to verify our results.
摘要：
X-射线修复交叉互补组3(XRCC3)是同源重组的有效组分,并且是在哺乳动物细胞中保持染色体完整性所必需的。该基因中的Thr241Met单核苷酸多态性（SNP）与乳腺癌易感性之间的关联已在多项研究中进行了评估。然而，报道有争议。本荟萃分析旨在确定该SNP是否与乳腺癌易感性相关。
我们进行了系统评价和荟萃分析，以检索关于T241MSNP与乳腺癌风险之间关联的病例对照研究。计算粗比值比(OR)和95%置信区间(CI)以验证显性关联，隐性,和纯合子遗传模型。
我们纳入了55项研究，包含30,966例散发性乳腺癌病例，荟萃分析中的1174例家族性乳腺癌病例和32,890例对照。在粗略的分析中，未检测到上述SNP与隐性乳腺癌风险之间的关联，纯合子或显性模型。然而,基于种族的分析表明，在散发性乳腺癌中，SNP与纯合子阿拉伯人群的乳腺癌风险相关（OR（95％CI）=3.649（2.029-6.563），p=0.0001)和隐性模型(OR(95%CI)=4.092(1.806-9.271)，p=0.001)。在显性模型的亚洲人群中，这种关联是显着的（OR（95％CI）=1.296，p=0.029）。然而,在纯合子和隐性模型中，家族性乳腺癌在基于种族的混合亚组中的相关性是显着的（OR（95％CI）=0.451（0.309-0.659），p=0.0001，OR（95%CI）=0.462（0.298-0.716），p分别=0.001)。
合照,我们在大量散发性和家族性乳腺癌病例样本中的结果显示,Thr241Met在此类恶性肿瘤的发病机制中作用不显著.这样的结果在零星病例中更具决定性。在家族性病例中,需要未来的研究来验证我们的结果.
我们进行了系统评价和荟萃分析，以检索关于T241MSNP与乳腺癌风险之间关联的病例对照研究。计算粗比值比(OR)和95%置信区间(CI)以验证显性关联，隐性,和纯合子遗传模型。
我们纳入了55项研究，包含30,966例散发性乳腺癌病例，荟萃分析中的1174例家族性乳腺癌病例和32,890例对照。在粗略的分析中，未检测到上述SNP与隐性乳腺癌风险之间的关联，纯合子或显性模型。然而,基于种族的分析表明，在散发性乳腺癌中，SNP与纯合子阿拉伯人群的乳腺癌风险相关（OR（95％CI）=3.649（2.029-6.563），p=0.0001)和隐性模型(OR(95%CI)=4.092(1.806-9.271)，p=0.001)。在显性模型的亚洲人群中，这种关联是显着的（OR（95％CI）=1.296，p=0.029）。然而,在纯合子和隐性模型中，家族性乳腺癌在基于种族的混合亚组中的相关性是显着的（OR（95％CI）=0.451（0.309-0.659），p=0.0001，OR（95%CI）=0.462（0.298-0.716），p分别=0.001)。
合照,我们在大量散发性和家族性乳腺癌病例样本中的结果显示,Thr241Met在此类恶性肿瘤的发病机制中作用不显著.这样的结果在零星病例中更具决定性。在家族性病例中,需要未来的研究来验证我们的结果.
