PDF(Sci-hub)
Abstract：
This review considers whether exposure to low-level radiofrequency (RF) fields, mostly associated with mobile phone technology, can influence cognitive behaviour of laboratory animals. Studies were nominated for inclusion using an a priori defined protocol with preselected criteria, and studies were excluded from analysis if they did not include sufficient details about the exposure, dosimetry or experimental protocol, or if they lacked a sham-exposed group. Overall, 62 studies were identified that have investigated the effects of RF fields on spatial memory and place learning and have been published since 1993. Of these, 17 studies were excluded, 20 studies reported no significant field-related effects, 21 studies reported significant impairments or deficits, and four studies reported beneficial consequences. The data do not suggest whether these outcomes are related to specific differences in exposure or testing conditions, or simply represent chance. However, some studies have suggested possible molecular mechanisms for the observed effects, but none of these has been substantiated through independent replication. Further behavioural studies could prove useful to resolve this situation, and it is suggested that these studies should use a consistent animal model with standardized exposure and testing protocols, and with detailed dosimetry provided by heterogeneous, anatomically-realistic animal models.
摘要：
这篇综述考虑了是否暴露于低水平射频(RF)场，主要与手机技术有关，可以影响实验动物的认知行为。使用具有预选标准的先验定义方案提名纳入研究，如果研究没有包括足够的暴露细节，则将其排除在分析之外，剂量测定或实验方案，或者他们缺少假暴露组.总的来说,已经确定了62项研究，这些研究调查了RF场对空间记忆和位置学习的影响，并且自1993年以来已发表。其中,17项研究被排除在外，20项研究报告没有显著的场相关效应，21项研究报告了显著的损伤或缺陷，四项研究报告了有益的后果。数据并未表明这些结果是否与暴露或测试条件的特定差异有关，或者只是代表机会。然而,一些研究提出了观察到的效应的可能分子机制，但是这些都没有通过独立复制得到证实。进一步的行为研究可以证明对解决这种情况有用，建议这些研究应使用具有标准化暴露和测试方案的一致动物模型，并由异质体提供详细的剂量测定，解剖学上真实的动物模型。
