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Abstract：
Genetic predisposition of social sensitivity might affect vulnerability to develop psychopathology after early life stress exposure. This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5-6 and 11-12. In the Amsterdam-Born-Children-and-their-Development (ABCD) study, a large observational, population-based birth cohort, maternal verbally aggressive behavior was assessed in the 13th postnatal week by a self-report questionnaire. Internalizing symptoms at age 5-6 were assessed by maternal report (N = 969) and internalizing symptoms at age 11-12 were assessed by self-report (N = 750). Data on oxytocin receptor polymorphisms rs53576 and rs2268498 and oxytocin polymorphisms rs2740210 and rs4813627 were collected. If the child was carrier of rs2740210 CA/AA polymorphism, exposure to maternal verbally aggressive behavior (10.6%) was positively associated with general anxiety at age 5-6 and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.015, respectively). If the child was carrier of rs4813627 GG (wild type), exposure to maternal verbally aggressive behavior was negatively associated with anxiety sensitivity and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.022, respectively). After exposure to maternal verbally aggressive behavior in early infancy, oxytocin polymorphisms may partly determine a child\'s vulnerability to internalizing symptoms.
摘要：
社会敏感性的遗传易感性可能会影响早期生活压力暴露后发展心理病理学的脆弱性。这项研究检查了母亲在婴儿早期的言语攻击行为是否与催产素多态性相互作用，从而在5-6岁和11-12岁时出现内在化症状。在阿姆斯特丹出生的儿童及其发展(ABCD)研究中，一个大型的观测，基于人口的出生队列，通过自我报告问卷在产后第13周评估了产妇的言语攻击行为.通过母亲报告评估5-6岁时的内化症状（N=969），通过自我报告评估11-12岁时的内化症状（N=750）。收集催产素受体多态性rs53576和rs2268498以及催产素多态性rs2740210和rs4813627的数据。如果孩子是rs2740210CA/AA多态性的携带者，母亲的言语攻击行为暴露(10.6%)与5-6岁时的一般焦虑和11-12岁时的情绪症状呈正相关(分别为p=0.011和p=0.015).如果孩子是rs4813627GG（野生型）的携带者，在11-12岁时,母亲的言语攻击行为与焦虑敏感性和情绪症状呈负相关(分别为p=0.011和p=0.022).在婴儿早期暴露于母亲的言语攻击行为后，催产素多态性可能部分决定了儿童对内在化症状的脆弱性。
