Diagnostic utility of transbronchial lung cryobiopsy: Two cases of anti-aminoacyl-tRNA synthetase syndrome with respiratory failure.

• 发表时间: Jul 2019
• 来源期刊: Respir Investig
• DOI: 10.1016/j.resinv.2019.03.002
• PMID: 31054836
• 文章类型: Case Reports
• 作者列表: Yoshimura H,Awano N,Inomata M,Kuse N,Tone M,Jo T,Takemura T,Kumasaka T,Izumo T

关键词: Anti-aminoacyl-tRNA synthetase antibody; Interstitial lung disease; Surgical lung biopsy; Transbronchial lung cryobiopsy

Mesh: Aged, 80 and over; Amino Acyl-tRNA Synthetases / immunology; Autoantibodies; Biopsy / methods; Bronchoscopy / methods; Cyclosporine / administration & dosage; Female; Humans; Immunosuppressive Agents / administration & dosage; Lung / pathology; Lung Diseases, Interstitial / diagnosis immunology pathology therapy; Male; Middle Aged; Oxygen Inhalation Therapy; Prednisolone / administration & dosage; Respiratory Insufficiency / immunology pathology therapy; Syndrome

Abstract

Transbronchial lung cryobiopsy (TBLC) is a useful and safe method for the diagnosis of interstitial lung disease (ILD). Herein, we describe the cases of two patients who developed ILD from anti-aminoacyl-tRNA synthetase syndrome with respiratory failure. TBLC was performed instead of surgical lung biopsy. There were no complications, and sufficient specimens were harvested to make the precise histopathological diagnosis. TBLC should be considered as a critical approach for the histopathological diagnosis of ILD in patients who cannot undergo surgical lung biopsy because of respiratory failure.