Progress in the Use of Induced Pluripotent Stem Cell-Derived Neural Cells for Traumatic Spinal Cord Injuries in Animal Populations: Meta-Analysis and Review.

• 影响指数: 7.655
• 发表时间: 07 2019
• 来源期刊: Stem Cells Transl Med
• DOI: 10.1002/sctm.18-0225
• PMID: 30903654
• 文章类型: Journal Article
• 中科院分区: Q2
• 方向: 生物
• 作者列表: Ramotowski C,Qu X,Villa-Diaz LG

关键词: Embryonic stem cells; Induced pluripotent stem cells; Meta-analysis; Regenerative medicine; Spinal cord injury

Mesh: Animals; Cell Differentiation; Human Embryonic Stem Cells / metabolism pathology; Humans; Induced Pluripotent Stem Cells / metabolism pathology; Neural Stem Cells / metabolism pathology transplantation; Recovery of Function; Spinal Cord Injuries / metabolism pathology therapy

Abstract

Induced pluripotent stem cells (iPSCs) are cells genetically reprogrammed from somatic cells, which can be differentiated into neurological lineages with the aim to replace or assist damaged neurons in the treatment of spinal cord injuries (SCIs) caused by physical trauma. Here, we review studies addressing the functional use of iPSC-derived neural cells in SCIs and perform a meta-analysis to determine if significant motor improvement is restored after treatment with iPSC-derived neural cells compared with treatments using embryonic stem cell (ESC)-derived counterpart cells and control treatments. Overall, based on locomotion scales in rodents and monkeys, our meta-analysis indicates a therapeutic benefit for SCI treatment using neural cells derived from either iPSCs or ESCs, being this of importance due to existing ethical and immunological complications using ESCs. Results from these studies are evidence of the successes and limitations of iPSC-derived neural cells in the recovery of motor capacity. Stem Cells Translational Medicine 2019;8:681&693.