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Abstract：
UNASSIGNED: Noise-induced hearing loss is a leading occupational disease caused by gene-environment interaction. The Grainy Like 2, GRHL2, is a candidate gene. In this regard, many studies have evaluated the association between GRHL2 and noise-induced hearing loss, although the results are ambiguous and conflicting.
OBJECTIVE: The purpose of this study was to identify a precise estimation of the association between rs3735715 polymorphism in GRHL2 gene and susceptibility of noise-induced hearing loss.
METHODS: A comprehensive search was performed to collect data up to July 8, 2018. Finally, 4 eligible articles were included in this meta-analysis comprising 2410 subjects. The pooled odds ratios with 95% confidence intervals were used to evaluate the strength of the association.
RESULTS: Significant association was found in the overall population in the dominant model (GA/AA vs. GG, odds ratio=0.707, 95% confidence interval=0.594-0.841) and allele model (G allele vs. A allele, odds ratio=1.189, 95% confidence interval=1.062-1.333). When stratified by source of the subjects, we also found association between rs3735715 and noise-induced hearing loss risk in the dominant model (GA/AA vs. GG, odds ratio=0.634, 95% confidence interval=0.514-0.783) and allele model (G allele vs. A allele, odds ratio=1.206, 95% confidence interval=1.054-1.379).
CONCLUSIONS: Rs3735715 polymorphism in GRHL2 gene may influence the susceptibility of noise-induced hearing loss. Additional large, well-designed and functional studies are needed to confirm this association in different populations.
OBJECTIVE: The purpose of this study was to identify a precise estimation of the association between rs3735715 polymorphism in GRHL2 gene and susceptibility of noise-induced hearing loss.
METHODS: A comprehensive search was performed to collect data up to July 8, 2018. Finally, 4 eligible articles were included in this meta-analysis comprising 2410 subjects. The pooled odds ratios with 95% confidence intervals were used to evaluate the strength of the association.
RESULTS: Significant association was found in the overall population in the dominant model (GA/AA vs. GG, odds ratio=0.707, 95% confidence interval=0.594-0.841) and allele model (G allele vs. A allele, odds ratio=1.189, 95% confidence interval=1.062-1.333). When stratified by source of the subjects, we also found association between rs3735715 and noise-induced hearing loss risk in the dominant model (GA/AA vs. GG, odds ratio=0.634, 95% confidence interval=0.514-0.783) and allele model (G allele vs. A allele, odds ratio=1.206, 95% confidence interval=1.054-1.379).
CONCLUSIONS: Rs3735715 polymorphism in GRHL2 gene may influence the susceptibility of noise-induced hearing loss. Additional large, well-designed and functional studies are needed to confirm this association in different populations.
摘要：
■噪声性听力损失是由基因-环境相互作用引起的一种主要职业病。GrainyLike2(GRHL2)是候选基因。在这方面,许多研究已经评估了GRHL2与噪声引起的听力损失之间的关系，尽管结果是模棱两可和相互矛盾的。
目的：这项研究的目的是确定GRHL2基因rs3735715多态性与噪声诱发的听力损失易感性之间的关联的精确估计。
方法：进行了全面搜索，以收集截至2018年7月8日的数据。最后,该荟萃分析中包括4篇符合条件的文章，包括2410名受试者。具有95％置信区间的合并比值比用于评估关联的强度。
结果：在显性模型的总体人群中发现了显着关联（GA/AA与GG,比值比=0.707，95%置信区间=0.594-0.841）和等位基因模型（G等位基因与一个等位基因,比值比=1.189，95%置信区间=1.062-1.333)。当按受试者来源分层时，在显性模型中，我们还发现rs3735715与噪声引起的听力损失风险之间存在关联(GA/AA与GG,比值比=0.634，95%置信区间=0.514-0.783）和等位基因模型（G等位基因与一个等位基因,比值比=1.206，95%置信区间=1.054-1.379)。
结论：GRHL2基因Rs3735715多态性可能影响噪声性听力损失的易感性。额外的大，需要精心设计的功能研究来确认不同人群的这种关联.
目的：这项研究的目的是确定GRHL2基因rs3735715多态性与噪声诱发的听力损失易感性之间的关联的精确估计。
方法：进行了全面搜索，以收集截至2018年7月8日的数据。最后,该荟萃分析中包括4篇符合条件的文章，包括2410名受试者。具有95％置信区间的合并比值比用于评估关联的强度。
结果：在显性模型的总体人群中发现了显着关联（GA/AA与GG,比值比=0.707，95%置信区间=0.594-0.841）和等位基因模型（G等位基因与一个等位基因,比值比=1.189，95%置信区间=1.062-1.333)。当按受试者来源分层时，在显性模型中，我们还发现rs3735715与噪声引起的听力损失风险之间存在关联(GA/AA与GG,比值比=0.634，95%置信区间=0.514-0.783）和等位基因模型（G等位基因与一个等位基因,比值比=1.206，95%置信区间=1.054-1.379)。
结论：GRHL2基因Rs3735715多态性可能影响噪声性听力损失的易感性。额外的大，需要精心设计的功能研究来确认不同人群的这种关联.
