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Abstract：
The first case of breast implant-associated anaplastic large cell lymphoma (breast implant ALCL) was described by John Keech and the late Brevator Creech in 1997. In the following 2 decades, much research has led to acceptance of breast implant ALCL as a specific clinicopathologic entity, a process that we bring up to life through the memories of 6 persons who were involved in this progress, although we acknowledge that many others also have contributed to the current state of the art of this disease. Dr. Keech recalls the events that led him and Creech to first report the disease. Ahmet Dogan and colleagues at the Mayo Clinic described a series of 4 patients with breast implant ALCL, and led to increased awareness of breast implant ALCL in the pathology community. Daphne de Jong and colleagues in the Netherlands were the first to provide epidemiologic evidence to support the association between breast implants and ALCL. Garry Brody was one of the first investigators to collect a large number of patients with the disease, present the spectrum of clinical findings, and alert the community of plastic surgeons. Roberto Miranda and L. Jeffrey Medeiros and colleagues studied the pathologic findings of a large number of cases of breast implant ALCL, and published the findings in 2 impactful studies in the medical oncology literature. The recognition and acceptance of this disease by surgeons, epidemiologists, and medical oncologists, working together, has led to subsequent studies on the pathogenesis and optimal therapy of this disease.
摘要：
1997年，JohnKeech和晚期BrevatorCreech描述了第一例乳房植入物相关的间变性大细胞淋巴瘤（乳房植入物ALCL）。在接下来的20年里，许多研究导致接受乳房植入物ALCL作为一种特定的临床病理实体，我们通过对参与这一进程的6个人的记忆来恢复生活的过程，尽管我们承认许多其他人也对这种疾病的最新发展做出了贡献。Keech博士回忆起导致他和Creech首次报告这种疾病的事件。Mayo诊所的AhmetDogan及其同事描述了一系列4例乳房植入物ALCL患者，并导致病理学界对乳房植入物ALCL的认识增加。DaphnedeJong和荷兰的同事是第一个提供流行病学证据来支持乳房植入物和ALCL之间的关联的人。GarryBrody是最早收集大量该疾病患者的研究人员之一，呈现临床发现的频谱，并提醒整形外科医生社区。RobertoMiranda和L.JeffreyMedeiros及其同事研究了大量乳房植入物ALCL病例的病理发现，并在医学肿瘤学文献中的两项有影响力的研究中发表了这一发现。外科医生对这种疾病的认可和接受，流行病学家，和医学肿瘤学家，一起工作,导致了对这种疾病的发病机理和最佳治疗方法的后续研究。
