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Abstract：
In addition to their critical role in allergic disorders, mast cells (MCs) are well recognized for their protective effector functions during bacteria and parasite infections. This review describes recent advancements of our understanding of the complex role of MCs in fungal infections. Specifically, we outline key features of the contribution of MCs to infections with six fungal pathogens, namely Sporothrix, Paracoccidioides, Aspergillus, Malassezia, Candida and Dermatophytes. Evidence from studies of these pathogens suggests that MCs can function as positive regulators that detect and contain fungi at the site of infection. However, it appears that the inflammation induced by MCs following fungal infections may not always and only be beneficial to the host. MC responses during fungal infections may primarily benefit the pathogen by facilitating its spreading and contributing to a greater severity of fungal infections. This review also highlights key drivers of MCs activation and effector mechanisms that have been identified for the multidimensional function of MCs in fungal diseases and in allergic diseases combined with fungal infection.
摘要：
除了它们在过敏性疾病中的关键作用，肥大细胞（MC）在细菌和寄生虫感染期间的保护性效应功能得到了很好的认可。这篇综述描述了我们对MC在真菌感染中的复杂作用的理解的最新进展。具体来说,我们概述了MC对六种真菌病原体感染的贡献的关键特征，即孢子丝虫，副球菌,曲霉菌,马拉色菌,念珠菌和皮肤癣菌。来自这些病原体的研究的证据表明,MC可以作为在感染部位检测和含有真菌的正调节因子。然而,似乎真菌感染后由MC诱导的炎症可能并不总是并且仅对宿主有益。真菌感染期间的MC反应可能主要通过促进病原体的传播并导致更严重的真菌感染而使病原体受益。这篇综述还强调了MCs激活的关键驱动因素和效应机制，这些机制已被确定为MCs在真菌疾病和过敏性疾病合并真菌感染中的多维功能。
