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Abstract：
Primary and secondary sterility have become an issue of increasing importance due to demographic and social changes in society. Data regarding the association between female androgen levels and the probability of successful conception after fertility treatment are sparse and contradictive. This study was designed to assess this clinical question.
In this retrospective single-center cohort study concentrations of androgens androstenedione, dehydroepiandrosteronsulfat (DHEAS) and testosterone (ng/ml) were investigated in the serum of patients presenting for sterility at the department of reproductive medicine of Saarland University hospital Homburg between January 2015 and December 2017. Androgen levels were correlated with reproductive outcomes. Statistical analysis was performed with the aid of SPSS version 24. Significance for conception rates in dependence of androgen concentration was assessed using Kruskal-Wallis test (significance was estimated with p < 0.05).
The laboratory values of a total of 301 patients were examined (64% primary, 36% secondary sterility). Median age at first visit at the fertility department was 32.7 years (range 20-47 years). 64 pregnancies were observed during the study period (conception rate 21.3%). 23 out of 301 patients (7.6%) suffered from hypoandrogenaemia, 248 (82.4%) had normal androgen levels and 30 (10%) showed hyperandrogenaemia (p = 0.25). Regarding patients in whom fertility treatment was successful 3 (4.7%) showed hypoandrogenaemia, 54 (84.4%) were normoandrogenaemic and 7 (10.9%) had hyperandrogenaemia (p = 0.40 Kruskal-Wallis test).
We found no association between female androgen levels and sterility and reproductive outcomes.
In this retrospective single-center cohort study concentrations of androgens androstenedione, dehydroepiandrosteronsulfat (DHEAS) and testosterone (ng/ml) were investigated in the serum of patients presenting for sterility at the department of reproductive medicine of Saarland University hospital Homburg between January 2015 and December 2017. Androgen levels were correlated with reproductive outcomes. Statistical analysis was performed with the aid of SPSS version 24. Significance for conception rates in dependence of androgen concentration was assessed using Kruskal-Wallis test (significance was estimated with p < 0.05).
The laboratory values of a total of 301 patients were examined (64% primary, 36% secondary sterility). Median age at first visit at the fertility department was 32.7 years (range 20-47 years). 64 pregnancies were observed during the study period (conception rate 21.3%). 23 out of 301 patients (7.6%) suffered from hypoandrogenaemia, 248 (82.4%) had normal androgen levels and 30 (10%) showed hyperandrogenaemia (p = 0.25). Regarding patients in whom fertility treatment was successful 3 (4.7%) showed hypoandrogenaemia, 54 (84.4%) were normoandrogenaemic and 7 (10.9%) had hyperandrogenaemia (p = 0.40 Kruskal-Wallis test).
We found no association between female androgen levels and sterility and reproductive outcomes.
摘要：
由于社会的人口和社会变化，原发性和继发性不育已成为越来越重要的问题。有关女性雄激素水平与生育治疗后成功受孕的可能性之间的关联的数据很少且相互矛盾。本研究旨在评估这一临床问题。
在这项回顾性单中心队列研究中，雄激素雄烯二酮的浓度，2015年1月至2017年12月,在萨尔州大学医院Homburg生殖医学系对出现不育症的患者血清中的脱氢表雄酮磺胺(DHEAS)和睾酮(ng/ml)进行了研究.雄激素水平与生殖结果相关。借助SPSS版本24进行统计分析。使用Kruskal-Wallis检验评估取决于雄激素浓度的受胎率的显著性(显著性估计为p<0.05)。
总共检查了301名患者的实验室值（64％的原发性，36%的次生不育)。生育部门首次就诊的中位年龄为32.7岁（范围20-47岁）。在研究期间观察到64例怀孕（受孕率21.3%）。301名患者中有23名(7.6%)患有低雄激素血症,248（82.4％）的雄激素水平正常，30（10％）的高雄激素血症（p=0.25）。关于生育治疗成功的患者3（4.7％）显示低雄激素血症，54（84.4％）为正常雄激素血症，7（10.9％）为高雄激素血症（p=0.40Kruskal-Wallis检验）。
我们发现女性雄激素水平与不育和生殖结局之间没有关联。
在这项回顾性单中心队列研究中，雄激素雄烯二酮的浓度，2015年1月至2017年12月,在萨尔州大学医院Homburg生殖医学系对出现不育症的患者血清中的脱氢表雄酮磺胺(DHEAS)和睾酮(ng/ml)进行了研究.雄激素水平与生殖结果相关。借助SPSS版本24进行统计分析。使用Kruskal-Wallis检验评估取决于雄激素浓度的受胎率的显著性(显著性估计为p<0.05)。
总共检查了301名患者的实验室值（64％的原发性，36%的次生不育)。生育部门首次就诊的中位年龄为32.7岁（范围20-47岁）。在研究期间观察到64例怀孕（受孕率21.3%）。301名患者中有23名(7.6%)患有低雄激素血症,248（82.4％）的雄激素水平正常，30（10％）的高雄激素血症（p=0.25）。关于生育治疗成功的患者3（4.7％）显示低雄激素血症，54（84.4％）为正常雄激素血症，7（10.9％）为高雄激素血症（p=0.40Kruskal-Wallis检验）。
我们发现女性雄激素水平与不育和生殖结局之间没有关联。
