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Abstract：
Objective Sinonasal undifferentiated carcinoma (SNUC) is an aggressive neoplasm, with conflicting existing literature regarding prognosis and treatment due to the rarity of disease. Characterization of optimal SNUC management is necessary for improved outcomes. Study Design Case series with planned data collection and analysis. Setting Hospital of the University of Pennsylvania and Pennsylvania Hospital. Participants Patients with pathologically confirmed SNUC treated within a 15-year period were identified, and records were obtained and evaluated for several demographic characteristics. Main Outcomes Measures Disease-specific survival from diagnosis was the primary endpoint, while disease recurrence was a secondary endpoint of the study. Results Twenty-seven patients with established SNUC were included in this cohort, with a median age of 55 years. Eighty-five percent of patients were surgically treated, and 85% of patients presented with stage IV disease. Two-year disease-specific survival was 66% and 5-year disease-specific survival was 46%. Ninety-six percent of patients received both chemotherapy and radiation as adjuvant treatment. Nodal disease at presentation and disease recurrence both significantly decreased patient survival ( p < 0.05). Conclusions The majority of patients at this institution presented with clinically advanced disease, and most were managed with a multimodal approach of surgical resection, chemotherapy, and radiation. Extent of disease at presentation and progression of disease following treatment are poor prognostic signs and may merit a more aggressive approach, while early detection and treatment may improve survival and decrease patient morbidity.
摘要：
目的鼻窦未分化癌(SNUC)是一种侵袭性肿瘤,由于罕见的疾病，关于预后和治疗的现有文献相互矛盾。最佳SNUC管理的表征对于改善结果是必要的。具有计划数据收集和分析的研究设计案例系列。设置宾夕法尼亚大学医院和宾夕法尼亚大学医院。参与者确定了在15年内接受病理证实为SNUC的患者，并获得记录并评估了几种人口统计学特征。主要结局指标诊断后的疾病特异性生存率是主要终点，而疾病复发是研究的次要终点.结果27例建立SNUC的患者被纳入该队列，平均年龄为55岁。85%的病人接受了手术治疗,85%的患者出现IV期疾病。2年疾病特异性生存率为66%，5年疾病特异性生存率为46%。96%的患者接受化疗和放疗作为辅助治疗。出现时的淋巴结疾病和疾病复发均显着降低了患者的生存率（p<0.05）。结论该机构的大多数患者患有临床晚期疾病，大多数都采用了多模式手术切除方法，化疗,和辐射。治疗后出现的疾病程度和疾病进展是预后不良的体征，可能值得采取更积极的方法。而早期发现和治疗可以提高生存率并降低患者发病率。
