Balanced between order and disorder: a new phase in transcription elongation control and beyond.

有序与无序之间的平衡 ： 转录延伸控制和超越的新阶段。

• 发表时间: 06 2019
• 来源期刊: Transcription
• DOI: 10.1080/21541264.2019.1570812
• PMID: 30663929
• 文章类型: Journal Article
• 作者列表: Lu H,Liu R,Zhou Q

关键词: P-TEFb; Phase separation; RNA polymerase II CTD; transcription elongation; transcriptional control

Mesh: Cyclin T / genetics metabolism; Histidine / metabolism; Humans; Phosphorylation; Positive Transcriptional Elongation Factor B / genetics metabolism; RNA Polymerase II / metabolism; Transcription, Genetic / genetics

Abstract

We recently reported that the cyclin T1 histidine-rich domain creates a phase-separated environment to promote hyperphosphorylation of RNA polymerase II C-terminal domain and robust transcriptional elongation by P-TEFb. Here, we discuss this and several other recent discoveries to demonstrate that phase separation is important for controlling various aspects of transcription.

摘要

我们最近报道，细胞周期蛋白T1组氨酸富集结构域创造了一个相分离的环境，以促进RNA聚合酶IIC末端结构域的过度磷酸化和P-TEFb的强大转录延伸。这里,我们讨论了这个和其他一些最近的发现，以证明相分离对于控制转录的各个方面很重要。