PDF(Sci-hub)
Abstract：
To evaluate the prognostic significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma (HNSCC).
We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta-analysis to quantify the impact of CTTN/cortactin alterations on clinicopathological and survival variables.
Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN/cortactin alterations with N+ status (P < .001), higher T status (P < .001), advanced clinical stage (P < .001), high histological grade (P = .001), and lower overall survival (OS) (P < .001). We found heterogeneity in T status, histological grade, and OS and observed small-study effects on N status and OS. In subgroup analyses, a significant association of CTTN amplification and cortactin overexpression with the above variables was preserved. The strongest association between CTTN/cortactin alterations and a worse outcome was observed in the subgroups of Asian patients and pharyngolaryngeal squamous cell carcinomas.
CTTN/cortactin alterations should be evaluated to predict the HNSCC prognosis.
We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta-analysis to quantify the impact of CTTN/cortactin alterations on clinicopathological and survival variables.
Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN/cortactin alterations with N+ status (P < .001), higher T status (P < .001), advanced clinical stage (P < .001), high histological grade (P = .001), and lower overall survival (OS) (P < .001). We found heterogeneity in T status, histological grade, and OS and observed small-study effects on N status and OS. In subgroup analyses, a significant association of CTTN amplification and cortactin overexpression with the above variables was preserved. The strongest association between CTTN/cortactin alterations and a worse outcome was observed in the subgroups of Asian patients and pharyngolaryngeal squamous cell carcinomas.
CTTN/cortactin alterations should be evaluated to predict the HNSCC prognosis.
摘要：
评价CTTN/cortactin改变在头颈部鳞状细胞癌(HNSCC)中的预后意义。
我们搜索了PubMed,Embase,WebofScience,和Scopus在2018年5月之前发表的研究。我们进行了一项荟萃分析，以量化CTTN/cortactin改变对临床病理和生存变量的影响。
18项研究（1633例患者）符合纳入标准。定量评估显示CTTN/cortactin改变与N+状态有很强的相关性（P<.001），较高的T状态（P<.001），晚期临床分期（P<.001），组织学分级高（P=.001），总生存期（OS）较低（P<0.001）。我们发现T状态存在异质性，组织学分级,和OS，并观察到小研究对N状态和OS的影响。在亚组分析中，保留了CTTN扩增和cortactin过表达与上述变量的显著关联.在亚洲患者和咽喉鳞状细胞癌的亚组中观察到CTTN/cortactin改变与不良预后之间最强的关联。
应评估CTTN/cortactin改变以预测HNSCC预后。
我们搜索了PubMed,Embase,WebofScience,和Scopus在2018年5月之前发表的研究。我们进行了一项荟萃分析，以量化CTTN/cortactin改变对临床病理和生存变量的影响。
18项研究（1633例患者）符合纳入标准。定量评估显示CTTN/cortactin改变与N+状态有很强的相关性（P<.001），较高的T状态（P<.001），晚期临床分期（P<.001），组织学分级高（P=.001），总生存期（OS）较低（P<0.001）。我们发现T状态存在异质性，组织学分级,和OS，并观察到小研究对N状态和OS的影响。在亚组分析中，保留了CTTN扩增和cortactin过表达与上述变量的显著关联.在亚洲患者和咽喉鳞状细胞癌的亚组中观察到CTTN/cortactin改变与不良预后之间最强的关联。
应评估CTTN/cortactin改变以预测HNSCC预后。
