{Reference Type}: Journal Article
{Title}: Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta-analysis.
{Author}: Ramos-García P;González-Moles MÁ;Ayén Á;González-Ruiz L;Ruiz-Ávila I;Gil-Montoya JA;
{Journal}: Head Neck
{Volume}: 41
{Issue}: 6
{Year}: 06 2019
{Factor}: 3.821
{DOI}: 10.1002/hed.25632
{Abstract}: To evaluate the prognostic significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma (HNSCC).<BR>We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta-analysis to quantify the impact of CTTN/cortactin alterations on clinicopathological and survival variables.<BR>Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN/cortactin alterations with N+ status (P < .001), higher T status (P < .001), advanced clinical stage (P < .001), high histological grade (P = .001), and lower overall survival (OS) (P < .001). We found heterogeneity in T status, histological grade, and OS and observed small-study effects on N status and OS. In subgroup analyses, a significant association of CTTN amplification and cortactin overexpression with the above variables was preserved. The strongest association between CTTN/cortactin alterations and a worse outcome was observed in the subgroups of Asian patients and pharyngolaryngeal squamous cell carcinomas.<BR>CTTN/cortactin alterations should be evaluated to predict the HNSCC prognosis.