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Abstract：
In recent years, substantial advances have been achieved in the design and synthesis of nonviral gene vectors. However, lack of effective and biocompatible vectors still remains a major challenge that hinders their application in clinical settings. In the past decade, there has been a rapid expansion of cationic antimicrobial polymers, due to their potent, rapid, and broad-spectrum biocidal activity against resistant microbes, and biocompatible features. Given that antimicrobial polymers share common features with nonviral gene vectors in various aspects, such as membrane affinity, functional groups, physicochemical characteristics, and unique macromolecular architectures, these polymers may provide us with inspirations to overcome challenges in the design of novel vectors toward more safe and efficient gene delivery in clinic. Building off these observations, we provide here an overview of the structure-function relationships of polymers for both antimicrobial applications and gene delivery by elaborating some key structural parameters, including functional groups, charge density, hydrophobic/hydrophilic balance, MW, and macromolecular architectures. By borrowing a leaf from antimicrobial agents, great advancement in the development of newer nonviral gene vectors with high transfection efficiency and biocompatibility will be more promising. STATEMENT OF SIGNIFICANCE: The development of gene delivery is still in the preclinical stage for the lack of effective and biocompatible vectors. Given that antimicrobial polymers share common features with gene vectors in various aspects, such as membrane affinity, functional groups, physicochemical characteristics, and unique macromolecular architectures, these polymers may provide us with inspirations to overcome challenges in the design of novel vectors toward more safe and efficient gene delivery in clinic. In this review, we systematically summarized the structure-function relationships of antimicrobial polymers and gene vectors, with which the design of more advanced nonviral gene vectors is anticipated to be further boosted in the future.
摘要：
近年来,在非病毒基因载体的设计和合成方面取得了重大进展。然而,缺乏有效和生物相容性载体仍然是阻碍其在临床应用的主要挑战.在过去的十年里,阳离子抗菌聚合物的迅速发展，由于他们的力量，快速,和对抗性微生物的广谱杀生物活性，和生物相容性特征。鉴于抗微生物聚合物在各个方面与非病毒基因载体具有共同的特征，如膜亲和力，功能组，物理化学特性，和独特的大分子结构，这些聚合物可能为我们提供了灵感，以克服设计新型载体的挑战，从而在临床上更安全有效地进行基因传递。基于这些观察，通过阐述一些关键的结构参数，我们在这里概述了用于抗菌应用和基因传递的聚合物的结构-功能关系，包括官能团，电荷密度,疏水/亲水平衡，MW,和大分子结构。从抗菌剂中借用一片叶子，具有高转染效率和生物相容性的新型非病毒基因载体的开发将更加有希望。重要声明：由于缺乏有效和生物相容性载体，基因递送的发展仍处于临床前阶段。鉴于抗微生物聚合物在各个方面与基因载体具有共同的特征，如膜亲和力，功能组，物理化学特性，和独特的大分子结构，这些聚合物可能为我们提供了灵感，以克服设计新型载体的挑战，从而在临床上更安全有效地进行基因传递。在这次审查中,系统总结了抗菌聚合物和基因载体的结构-功能关系,与之相比，更先进的非病毒基因载体的设计有望在未来得到进一步加强。
