Abstract：
Helminthiases caused by parasitic nematodes are widespread in different regions of the world. The main adaptation for overcoming adverse conditions is a barrier properties of the cuticle surface structure, which differs from the membrane teguments of trematodes and cestodes. Different types of nematodes have specific structural and biochemical adaptations at different stages of their life cycle. While creating specific areas of habitat and nutrition, some types of parasites change the morphology and functioning of the host tissues. Ascaris suum and Caenorabditis elegans were widely used as model organisms in the study of genetics, biochemistry of nematodes. Studying of biochemistry and molecular biology of structural components of nematode surfaces is important for development of effective and safe anthelmintic drugs. The differences in the structure and functioning of transport enzymes of parasites and humans will help to create effective specific inhibitors and anthelmintic remedies. An important point of application of anthelmintic drugs can serve as inorganic ions transport proteins in the membranes of the surfaces. Glycolipids of cuticle contribute to the evasion from the host immune system, protecting the surface proteins from degradation by proteases. Study of helminth surfaces makes an important contribution to the development of anthelmintic drugs and vaccines, for helminthiasis treat.
摘要：
由寄生线虫引起的蠕虫酶在世界不同地区普遍存在。克服不利条件的主要适应是角质层表面结构的屏障特性，它不同于吸虫和棘突的膜层。不同类型的线虫在其生命周期的不同阶段具有特定的结构和生化适应。在创造特定的栖息地和营养区域的同时，某些类型的寄生虫会改变宿主组织的形态和功能。蛔虫和秀丽隐杆线虫在遗传学研究中被广泛用作模型生物,线虫的生物化学。研究线虫表面结构成分的生物化学和分子生物学对于开发有效和安全的驱虫药物具有重要意义。寄生虫和人类转运酶的结构和功能差异将有助于创造有效的特异性抑制剂和驱虫药。驱虫药物的一个重要应用点可以作为表面膜中的无机离子转运蛋白。角质层的糖脂有助于逃避宿主免疫系统，保护表面蛋白质免受蛋白酶的降解。蠕虫表面的研究为驱虫药物和疫苗的开发做出了重要贡献，用于蠕虫病治疗。
