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Abstract：
The aim of the present study was to evaluate the association between xeroderma pigmentosum group C (XPC) polymorphisms and pancreatic cancer (PC) risk. A total of 7 XPC tagging SNPs (tag-SNPs) were selected from the International HapMap Project Databases (rs2228001A/C, rs2470353G/C, rs2228000C/T, rs3731114C/G, rs3729587G/C, rs2607775C/G and rs3731055G/A) and were genotyped in 205 patients with PC and 230 non-cancer control subjects using a SNaPshot assay. The C allelic gene frequency of rs2470353 was higher in patients with PC compared with that in the control group (P=0.003). Compared with the GG gene type, PC risk was increased in subjects with GC and GC+CC gene types (P=0.012 and P=0.006, respectively). PC risk increased 3.505-fold for the subjects who were heavy smokers (tobacco, ≥25 packets/year) with the GC+CC gene type (P=0.008). The G allelic gene frequency of rs2607775 was higher in PC patients compared with that in the control group (P=0.003). Compared with the CC gene type, PC risk increased in subjects with CG and CG+GG gene types (P=0.013 and P=0.005, respectively). Furthermore, PC risk increased 3.950-fold in subjects who were heavy smokers (tobacco, ≥25 packets/year) with the CG+GG gene type (P=0.001). Haplotype analysis further revealed that the CCC haplotype of rs2228000, rs3731114 and rs3729587 increased PC risk (odds ratio, 1.610; 95% confidence interval, 1.035-2.481; P=0.034). The present study revealed that XPC gene polymorphisms could increase the risk of PC in the study population, particularly among heavy smokers.
摘要：
本研究的目的是评估色素性干皮病C组（XPC）多态性与胰腺癌（PC）风险之间的关联。从国际HapMap项目数据库（rs2228001A/C，rs2470353G/C,rs2228000C/T,rs3731114C/G,rs3729587G/C,rs2607775C/G和rs3731055G/A），并使用SNaPshot测定法对205名PC患者和230名非癌症对照受试者进行了基因分型。与对照组相比，PC患者rs2470353的C等位基因频率更高（P=0.003）。与GG基因型相比，患有GC和GC+CC基因型的受试者的PC风险增加（分别为P=0.012和P=0.006）。重度吸烟者的PC风险增加了3.505倍(烟草，≥25包/年)与GC+CC基因类型(P=0.008)。PC患者rs2607775的G等位基因频率高于对照组（P=0.003）。与CC基因型相比，具有CG和CG+GG基因类型的受试者的PC风险增加(分别为P=0.013和P=0.005)。此外，重度吸烟者的PC风险增加了3.950倍(烟草，≥25包/年）与CG+GG基因类型（P=0.001）。单倍型分析进一步显示，rs2228000，rs3731114和rs3729587的CCC单倍型增加了PC风险（优势比，1.610；95%置信区间，1.035-2.481；P=0.034）。本研究表明，XPC基因多态性可增加研究人群患PC的风险，尤其是重度吸烟者。
