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Abstract：
OBJECTIVE: To evaluate height, sexual maturation, and the difference between final and expected height in girls with juvenile idiopathic arthritis and no glucocorticoid treatment for at least six months, as compared to a group of healthy girls.
METHODS: This cross-sectional study involved 44 girls with juvenile idiopathic arthritis, diagnosed according to the International League of Associations for Rheumatology criteria, and 59 healthy controls aged between 8 and 18 (incomplete) years with no comorbid chronic diseases. Demographic data were collected from all participants, and disease and treatment variables were compiled for the patient group. Anthropometric measurements were converted into Z-scores based on World Health Organization standards. Sexual maturation was classified according to Tanner stages.
RESULTS: Body mass index and height Z-scores were lower in girls with juvenile idiopathic arthritis as compared to control participants. These values differed significantly in Tanner stage II. Three (6.8%) girls with juvenile idiopathic arthritis had height-for-age Z-scores <-2 (short stature). Girls with polyarticular juvenile idiopathic arthritis and higher cumulative glucocorticoid doses were significantly more likely to present with short stature. The percentage of prepubertal girls in the juvenile idiopathic arthritis group was significantly higher than that observed in the control group, (p=0.012). Age of menarche, adult height, and the difference between actual and expected height did not differ between groups.
CONCLUSIONS: These findings suggest that even six months after the suspension of glucocorticoid treatment, children with polyarticular/systemic juvenile idiopathic arthritis subtypes are still susceptible to low height and delayed puberty.
METHODS: This cross-sectional study involved 44 girls with juvenile idiopathic arthritis, diagnosed according to the International League of Associations for Rheumatology criteria, and 59 healthy controls aged between 8 and 18 (incomplete) years with no comorbid chronic diseases. Demographic data were collected from all participants, and disease and treatment variables were compiled for the patient group. Anthropometric measurements were converted into Z-scores based on World Health Organization standards. Sexual maturation was classified according to Tanner stages.
RESULTS: Body mass index and height Z-scores were lower in girls with juvenile idiopathic arthritis as compared to control participants. These values differed significantly in Tanner stage II. Three (6.8%) girls with juvenile idiopathic arthritis had height-for-age Z-scores <-2 (short stature). Girls with polyarticular juvenile idiopathic arthritis and higher cumulative glucocorticoid doses were significantly more likely to present with short stature. The percentage of prepubertal girls in the juvenile idiopathic arthritis group was significantly higher than that observed in the control group, (p=0.012). Age of menarche, adult height, and the difference between actual and expected height did not differ between groups.
CONCLUSIONS: These findings suggest that even six months after the suspension of glucocorticoid treatment, children with polyarticular/systemic juvenile idiopathic arthritis subtypes are still susceptible to low height and delayed puberty.
摘要：
目的：为了评估身高，性成熟,以及幼年特发性关节炎且至少六个月没有糖皮质激素治疗的女孩最终身高和预期身高之间的差异，与一群健康的女孩相比。
方法：这项横断面研究涉及44名患有幼年特发性关节炎的女孩，根据国际风湿病协会联盟标准诊断，和59名健康对照，年龄在8至18岁（不完整）之间，没有共患慢性病。从所有参与者那里收集了人口统计数据，并编制了患者组的疾病和治疗变量.根据世界卫生组织的标准将人体测量值转换为Z分数。根据Tanner阶段对性成熟进行分类。
结果：青少年特发性关节炎女孩的体重指数和身高Z评分低于对照组。这些值在Tanner阶段II中存在显着差异。三名（6.8％）患有幼年特发性关节炎的女孩的身高年龄Z评分<-2（身材矮小）。患有多关节型幼年特发性关节炎和较高累积糖皮质激素剂量的女孩更有可能出现身材矮小。幼年特发性关节炎组的青春期前女童比例明显高于对照组,（p=0.012）。初潮年龄,成人身高,实际身高和预期身高之间的差异在组间没有差异.
结论：这些发现表明，即使在暂停糖皮质激素治疗后六个月，患有多关节/系统性幼年特发性关节炎亚型的儿童仍易患低身高和青春期延迟.
方法：这项横断面研究涉及44名患有幼年特发性关节炎的女孩，根据国际风湿病协会联盟标准诊断，和59名健康对照，年龄在8至18岁（不完整）之间，没有共患慢性病。从所有参与者那里收集了人口统计数据，并编制了患者组的疾病和治疗变量.根据世界卫生组织的标准将人体测量值转换为Z分数。根据Tanner阶段对性成熟进行分类。
结果：青少年特发性关节炎女孩的体重指数和身高Z评分低于对照组。这些值在Tanner阶段II中存在显着差异。三名（6.8％）患有幼年特发性关节炎的女孩的身高年龄Z评分<-2（身材矮小）。患有多关节型幼年特发性关节炎和较高累积糖皮质激素剂量的女孩更有可能出现身材矮小。幼年特发性关节炎组的青春期前女童比例明显高于对照组,（p=0.012）。初潮年龄,成人身高,实际身高和预期身高之间的差异在组间没有差异.
结论：这些发现表明，即使在暂停糖皮质激素治疗后六个月，患有多关节/系统性幼年特发性关节炎亚型的儿童仍易患低身高和青春期延迟.
