关键词: ALS amyotrophic lateral sclerosis molecular taxonomy multiomic analysis neurodegenerative disease personalized medicine signaling pathways

来  源:   DOI:10.3389/fnins.2018.00673   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Recent landmark publications from our research group outline a transformative approach to defining, studying and treating amyotrophic lateral sclerosis (ALS). Rather than approaching ALS as a single entity, we advocate targeting therapies to distinct \"clusters\" of patients based on their specific genomic and molecular features. Our findings point to the existence of a molecular taxonomy for ALS, bringing us a step closer to the establishment of a precision medicine approach in neurology practice.
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