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Abstract：
Esophageal squamous cell precursor lesions remain one of the most controversial topics in pathology and clinical management.
To analyze the dysregulation of human telomerase RNA component (hTERC) in esophageal squamous cell precursor lesions and the clinicopathological correlations with the characteristics of esophageal squamous cell precursor lesions.
Florescence in situ hybridization was performed to detect hTERC amplification in different gradings of esophageal squamous cell precursor lesions. With retrospective follow-up data, clinicopathological correlations between hTERC and esophageal squamous cell precursor lesions were subjected to logistic regression analysis.
hTERC amplification gradually increased with upgrading of dysplasia, reaching the highest level in high-grade intraepithelial neoplasia, and there was a significant difference between the low-grade intraepithelial neoplasia group and the high-grade intraepithelial neoplasia group (P = 0.00). Logistic regression analysis showed that hTERC amplification was correlated with both dysplasia grading and ulcer characteristics of esophageal squamous cell precursor lesions (P < 0.05).
hTERC amplification with increasing grading of esophageal squamous cell precursor lesions and the presence of ulcer characteristics might provide an important molecular and pathological marker for the diagnosis and clinical prognosis of esophageal squamous cell precursor lesions, especially for those ambiguous cases with more divergence in classification.
To analyze the dysregulation of human telomerase RNA component (hTERC) in esophageal squamous cell precursor lesions and the clinicopathological correlations with the characteristics of esophageal squamous cell precursor lesions.
Florescence in situ hybridization was performed to detect hTERC amplification in different gradings of esophageal squamous cell precursor lesions. With retrospective follow-up data, clinicopathological correlations between hTERC and esophageal squamous cell precursor lesions were subjected to logistic regression analysis.
hTERC amplification gradually increased with upgrading of dysplasia, reaching the highest level in high-grade intraepithelial neoplasia, and there was a significant difference between the low-grade intraepithelial neoplasia group and the high-grade intraepithelial neoplasia group (P = 0.00). Logistic regression analysis showed that hTERC amplification was correlated with both dysplasia grading and ulcer characteristics of esophageal squamous cell precursor lesions (P < 0.05).
hTERC amplification with increasing grading of esophageal squamous cell precursor lesions and the presence of ulcer characteristics might provide an important molecular and pathological marker for the diagnosis and clinical prognosis of esophageal squamous cell precursor lesions, especially for those ambiguous cases with more divergence in classification.
摘要：
食管鳞状细胞前体病变仍然是病理学和临床治疗中最有争议的话题之一。
分析人端粒酶RNA组分(hTERC)在食管鳞状细胞前体病变中的表达异常及其与食管鳞状细胞前体病变特点的临床病理相关性。
进行荧光原位杂交以检测不同级别食管鳞状细胞前体病变中的hTERC扩增。通过回顾性随访数据，对hTERC与食管鳞状细胞前体病变的临床病理相关性进行logistic回归分析。
hTERC扩增随着发育不良的升级而逐渐增加，在高级别上皮内瘤变中达到最高水平，低级别上皮内瘤变组和高级别上皮内瘤变组之间存在显着差异（P=0.00）。Logistic回归分析显示，hTERC扩增与食管鳞状细胞前体病变的异型增生分级和溃疡特征相关（P<0.05）。
随着食管鳞状细胞前体病变分级的增加和溃疡特征的存在，hTERC扩增可能为食管鳞状细胞前体病变的诊断和临床预后提供重要的分子和病理标志物。特别是对于那些分类分歧更大的模棱两可的情况。
分析人端粒酶RNA组分(hTERC)在食管鳞状细胞前体病变中的表达异常及其与食管鳞状细胞前体病变特点的临床病理相关性。
进行荧光原位杂交以检测不同级别食管鳞状细胞前体病变中的hTERC扩增。通过回顾性随访数据，对hTERC与食管鳞状细胞前体病变的临床病理相关性进行logistic回归分析。
hTERC扩增随着发育不良的升级而逐渐增加，在高级别上皮内瘤变中达到最高水平，低级别上皮内瘤变组和高级别上皮内瘤变组之间存在显着差异（P=0.00）。Logistic回归分析显示，hTERC扩增与食管鳞状细胞前体病变的异型增生分级和溃疡特征相关（P<0.05）。
随着食管鳞状细胞前体病变分级的增加和溃疡特征的存在，hTERC扩增可能为食管鳞状细胞前体病变的诊断和临床预后提供重要的分子和病理标志物。特别是对于那些分类分歧更大的模棱两可的情况。
