METHODS: A literature search was conducted in electronic databases up to September 1, 2018. Beta, Odds Ratio (OR) and corresponding 95% confidence intervals (95%CI) were calculated to estimate the effects of rs1378942 on SBP, DBP and hypertension. Quanto software was used to estimate the statistical power.
RESULTS: The results showed that the rs1378942 polymorphism significantly affected blood pressure levels in Asians, the C allele carriers had higher SBP and DBP levels: beta (95%CI): 0.71(0.38-1.04), P = 2.579 × 10-5, I2 = 43.5%, and beta (95%CI): 0.33(0.18-0.49), P = 2.092 × 10-5, I2 = 28.3%, respectively. This association was also found in East Asians, but not in South Asians. Furthermore, no significant association was observed with hypertension: OR (95%CI): 1.10 (0.97-1.25), P = .129, I2 = 81.2%.
CONCLUSIONS: The meta-analysis demonstrates that the C allele of the CSK rs1378942 is associated with higher SBP and DBP levels in East Asians.