{Reference Type}: Journal Article
{Title}: C-src tyrosine kinase gene rs1378942 polymorphism and hypertension in Asians: Review and meta-analysis.
{Author}: Qian X;Li Y;Liu X;Tu R;Tian Z;Zhang H;Zhang X;Zhou W;Jiang J;Wang Y;Bie R;Wang C;
{Journal}: Clin Chim Acta
{Volume}: 487
{Issue}: 0
{Year}: Dec 2018
{Factor}: 6.314
{DOI}: 10.1016/j.cca.2018.10.003
{Abstract}: <B>BACKGROUND: </B>The risk allele frequency of rs1378942 of c-src tyrosine kinase (CSK) gene is much higher in Asians (~ 0.80) than that in Europeans (~ 0.35), and the association between rs1378942 and blood pressure is controversial in Asians. Thus, the review and meta-analysis was performed to explore the effects of rs1378942 polymorphism on systolic blood pressure (SBP), diastolic blood pressure (DBP) levels and hypertension in Asians.<BR><B>METHODS: </B>A literature search was conducted in electronic databases up to September 1, 2018. Beta, Odds Ratio (OR) and corresponding 95% confidence intervals (95%CI) were calculated to estimate the effects of rs1378942 on SBP, DBP and hypertension. Quanto software was used to estimate the statistical power.<BR><B>RESULTS: </B>The results showed that the rs1378942 polymorphism significantly affected blood pressure levels in Asians, the C allele carriers had higher SBP and DBP levels: beta (95%CI): 0.71(0.38-1.04), P = 2.579 × 10-5, I2 = 43.5%, and beta (95%CI): 0.33(0.18-0.49), P = 2.092 × 10-5, I2 = 28.3%, respectively. This association was also found in East Asians, but not in South Asians. Furthermore, no significant association was observed with hypertension: OR (95%CI): 1.10 (0.97-1.25), P = .129, I2 = 81.2%.<BR><B>CONCLUSIONS: </B>The meta-analysis demonstrates that the C allele of the CSK rs1378942 is associated with higher SBP and DBP levels in East Asians.