别孕烯醇酮治疗改善脆性 X 相关震颤 / 共济失调综合征中与 GABA 代谢相关的血浆代谢谱 : 一项初步研究。
关键词: Allopregnanolone Bioenergetics FXTAS GABA Lymphocytes Pharmacometabolomics
Mesh : Aged Anxiety / blood complications drug therapy Ataxia / blood drug therapy metabolism Depression / blood complications drug therapy Energy Metabolism Fragile X Syndrome / blood drug therapy metabolism Humans Male Metabolomics Middle Aged Mitochondria / drug effects metabolism Ornithine / analogs & derivatives metabolism Oxidative Stress / drug effects Pilot Projects Pregnanolone / pharmacology therapeutic use Tremor / blood drug therapy metabolism gamma-Aminobutyric Acid / metabolism
来 源:
DOI:10.1007/s12035-018-1330-3
PDF(Sci-hub)
PDF(Pubmed)