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Abstract：
Wnt proteins, a group of secreted glycoproteins, mainly combine with receptors Frizzled (FZD) and/or low-density-lipoprotein receptor-related proteins 5/6 (LRP5/6), initiating β-catenin-dependent and -independent signaling pathways. These pathways, which can be regulated by some secreted antagonists such as secreted Frizzled-related proteins (SFRP) and dickkopf-related protein (DKK), play a critical role in embryo development and adult homeostasis. Overactivation of Wnt signaling has been implicated in some human diseases including cancer. Wnt transgenic mice provide convincing evidence that Wnt signaling is involved in breast cancer initiation and progression, which is further strengthened by observations on human clinical breast cancer patients and studies on in vitro cultured human breast cancer cells. This review focuses on the roles of Wnt ligands, receptors and antagonists in breast cancer development instead of molecules or signaling transactivating β-catenin independent on Wnt upstream components.
摘要：
Wnt蛋白,一组分泌的糖蛋白，主要与受体Frizzled（FZD）和/或低密度脂蛋白受体相关蛋白5/6（LRP5/6）结合，启动β-连环蛋白依赖性和非依赖性信号通路。这些途径,它可以被一些分泌的拮抗剂调节，如分泌的卷曲相关蛋白（SFRP）和dickkopf相关蛋白（DKK），在胚胎发育和成体稳态中起关键作用。Wnt信号传导的过度活化已经涉及包括癌症的一些人类疾病。Wnt转基因小鼠提供了令人信服的证据，证明Wnt信号与乳腺癌的发生和发展有关。对人类临床乳腺癌患者的观察和对体外培养的人乳腺癌细胞的研究进一步加强了这一点。本文综述了Wnt配体的作用,乳腺癌发展中的受体和拮抗剂，而不是独立于Wnt上游成分的分子或信号反式激活β-catenin。
