关键词: Agranulocytosis Neutropenic fever Waldenström

Mesh : Aged Agranulocytosis / diagnosis etiology Antineoplastic Combined Chemotherapy Protocols / therapeutic use Cyclophosphamide / administration & dosage Dexamethasone / administration & dosage Female Humans Leukocyte Count Neutrophils / cytology Positron Emission Tomography Computed Tomography Rituximab / administration & dosage Waldenstrom Macroglobulinemia / complications diagnosis drug therapy

来  源:   DOI:10.1159/000489482

Abstract:
Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. This is a case report of a woman with a past medical history of WM who presented with neutropenic fever. The patient\'s febrile neutropenia resolved after RCD chemotherapy (cyclophosphamide 750 mg/m2, dexamethasone 20 mg, and rituximab 375 mg/m2). Fourteen days after administration, the neutrophil level had started to rise and normalized after 6 days. To the best of our knowledge, this is the 3rd reported case of agranulocytosis due to WM.
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