Abstract：
Vascular pathology is increasingly acknowledged as a risk factor for multiple sclerosis (MS). Vascular density (VD) is reduced in the eyes of patients with MS on optical coherence tomography (OCT) angiography. We performed a 1-year prospective study to estimate VD variations over time and possible clinical correlates.
A total of 50 patients with MS underwent spectral domain-OCT and OCT angiography at baseline and after 1-year follow-up. Mixed-effect linear regression models were used to assess variations of each OCT measure and its relation to treatment and clinical outcomes.
We observed an increase in parafovea VD (coefficient, 1.147; 95% confidence interval, 0.081-2.214; P = 0.035). Reduction in parafovea VD was associated with increase in Expanded Disability Status Scale score (coefficient, -0.969; 95% confidence interval, -1.732/-0.207; P = 0.013).
Retinal VD can improve over time in MS, particularly in patients experiencing disease stability. Longer follow-up, inclusion of early MS cases and combination with conventional markers of MS severity (i.e. brain atrophy) are needed to better define VD as a potential new biomarker.
A total of 50 patients with MS underwent spectral domain-OCT and OCT angiography at baseline and after 1-year follow-up. Mixed-effect linear regression models were used to assess variations of each OCT measure and its relation to treatment and clinical outcomes.
We observed an increase in parafovea VD (coefficient, 1.147; 95% confidence interval, 0.081-2.214; P = 0.035). Reduction in parafovea VD was associated with increase in Expanded Disability Status Scale score (coefficient, -0.969; 95% confidence interval, -1.732/-0.207; P = 0.013).
Retinal VD can improve over time in MS, particularly in patients experiencing disease stability. Longer follow-up, inclusion of early MS cases and combination with conventional markers of MS severity (i.e. brain atrophy) are needed to better define VD as a potential new biomarker.
摘要：
血管病理学越来越被认为是多发性硬化症（MS）的危险因素。在光学相干断层扫描（OCT）血管造影中，MS患者的眼睛血管密度（VD）降低。我们进行了一项为期1年的前瞻性研究，以估计VD随时间的变化以及可能的临床相关性。
共有50例MS患者在基线和1年随访后接受谱域OCT和OCT血管造影。混合效应线性回归模型用于评估每个OCT测量的变化及其与治疗和临床结果的关系。
我们观察到旁瓣VD的增加(系数，1.147；95%置信区间，0.081-2.214；P=0.035）。副房型VD的减少与扩展残疾状态量表评分的增加相关(系数，-0.969；95%置信区间，-1.732/-0.207；P=0.013）。
视网膜VD在MS中可以随着时间的推移而改善，特别是在经历疾病稳定的患者中。更长时间的随访，需要纳入早期MS病例并结合MS严重程度(即脑萎缩)的常规标志物,以更好地将VD定义为潜在的新生物标志物.
共有50例MS患者在基线和1年随访后接受谱域OCT和OCT血管造影。混合效应线性回归模型用于评估每个OCT测量的变化及其与治疗和临床结果的关系。
我们观察到旁瓣VD的增加(系数，1.147；95%置信区间，0.081-2.214；P=0.035）。副房型VD的减少与扩展残疾状态量表评分的增加相关(系数，-0.969；95%置信区间，-1.732/-0.207；P=0.013）。
视网膜VD在MS中可以随着时间的推移而改善，特别是在经历疾病稳定的患者中。更长时间的随访，需要纳入早期MS病例并结合MS严重程度(即脑萎缩)的常规标志物,以更好地将VD定义为潜在的新生物标志物.
