CCR2 + 单核细胞来源的浸润巨噬细胞在压力过载期间需要用于不良心脏重塑。
关键词: APC, antigen presenting cell BNP, B-type natriuretic peptide CCL, C-C motif chemokine ligand CCR2, C-C chemokine receptor 2 DC, dendritic cell EDTA, ethylenediaminetetraacetic acid EF, ejection fraction HF, heart failure ICAM, intercellular adhesion molecule IFN, interferon IL, interleukin LN, lymph node LV, left ventricular MerTK, c-mer proto-oncogene tyrosine kinase PBS, phosphate-buffered saline T cells TAC, transverse aortic constriction TGF, transforming growth factor TNF, tumor necrosis factor VCAM, vascular cell adhesion molecule cardiac remodeling heart failure i.p., intraperitoneally inflammation macrophages
来 源:
DOI:10.1016/j.jacbts.2017.12.006
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