关键词: Colonic-derived flavonoid metabolites Epicatechin Glucose homeostasis Glucotoxicity Insulin signalling pathway NRK-52E cells
Mesh : 3,4-Dihydroxyphenylacetic Acid / pharmacology Adenylate Kinase / metabolism Animals Catechin / metabolism pharmacology Cell Line Colon / metabolism Down-Regulation Gluconeogenesis / drug effects Glucose / metabolism toxicity Glucose Transporter Type 2 / metabolism Glycogen Synthase Kinase 3 beta / metabolism Homeostasis Insulin / metabolism Intracellular Signaling Peptides and Proteins / metabolism Kidney Tubules, Proximal / cytology drug effects enzymology metabolism Phosphoenolpyruvate Carboxykinase (GTP) / metabolism Phosphorylation Proto-Oncogene Proteins c-akt / metabolism Rats Signal Transduction / drug effects Sodium-Glucose Transporter 2 / metabolism Tyrosine / metabolism Up-Regulation
来 源: DOI:10.1016/j.fct.2018.07.003