METHODS: We performed a microbiologic investigation on 53 female patients with biliopancreatic diseases who granted consent, and we analysed the data using a MATLAB platform.
RESULTS: We found that the most frequent disease associated with bactibilia was pancreas head carcinoma (PHC) (P=0.0015), while the least frequent disease was gall bladder carcinoma (GBC) (P=0.0002). The most common microorganisms were Pseudomonas spp. (P<0.0001) and Escherichia coli (P<0.0001). In particular Pseudomonas spp. and E. coli were negatively correlated to PHC presence and positively correlated to CCA by both univariate and multivariate analysis.
CONCLUSIONS: Gram-negative bacteria have been linked to a tumour-associated inflammatory status. In the last 30 years, the analysis of mortality rate in Italy for PHC and GBC shows an increasing and a decreasing trend, respectively. Although this study targeted only 53 patients and does not reflect the frequency of diagnosis in a Southern Italian population, the decrease in GBC may raise the suggestion ofnon-adherence to a Mediterranean diet that may have become more prevalent in Southern Italy since the 1990s.
方法:我们对53名女性胆胰疾病患者进行了微生物学调查,我们使用MATLAB平台对数据进行了分析。
结果:我们发现,最常见的疾病与bactbilia相关是胰头癌(PHC)(P=0.0015),而最不常见的疾病是胆囊癌(GBC)(P=0.0002)。最常见的微生物是假单胞菌属。(P<0.0001)和大肠杆菌(P<0.0001)。特别是假单胞菌属。通过单变量和多变量分析,大肠杆菌与PHC的存在呈负相关,与CCA呈正相关。
结论:革兰氏阴性菌与肿瘤相关的炎症状态有关。在过去的30年里,意大利PHC和GBC的死亡率分析显示出上升和下降的趋势,分别。尽管这项研究仅针对53名患者,但并未反映出意大利南部人群的诊断频率,GBC的减少可能会提出不遵守地中海饮食的建议,自1990年代以来,地中海饮食在意大利南部变得更加普遍。