Abstract：
OBJECTIVE: Bile is a hepatobiliary lipid-rich sterile solution, and its colonization by microorganisms defines the condition of bactibilia. In this study, we aimed to assess the bile microbiological flora and its potential link with comorbidity in women.
METHODS: We performed a microbiologic investigation on 53 female patients with biliopancreatic diseases who granted consent, and we analysed the data using a MATLAB platform.
RESULTS: We found that the most frequent disease associated with bactibilia was pancreas head carcinoma (PHC) (P=0.0015), while the least frequent disease was gall bladder carcinoma (GBC) (P=0.0002). The most common microorganisms were Pseudomonas spp. (P<0.0001) and Escherichia coli (P<0.0001). In particular Pseudomonas spp. and E. coli were negatively correlated to PHC presence and positively correlated to CCA by both univariate and multivariate analysis.
CONCLUSIONS: Gram-negative bacteria have been linked to a tumour-associated inflammatory status. In the last 30 years, the analysis of mortality rate in Italy for PHC and GBC shows an increasing and a decreasing trend, respectively. Although this study targeted only 53 patients and does not reflect the frequency of diagnosis in a Southern Italian population, the decrease in GBC may raise the suggestion ofnon-adherence to a Mediterranean diet that may have become more prevalent in Southern Italy since the 1990s.
METHODS: We performed a microbiologic investigation on 53 female patients with biliopancreatic diseases who granted consent, and we analysed the data using a MATLAB platform.
RESULTS: We found that the most frequent disease associated with bactibilia was pancreas head carcinoma (PHC) (P=0.0015), while the least frequent disease was gall bladder carcinoma (GBC) (P=0.0002). The most common microorganisms were Pseudomonas spp. (P<0.0001) and Escherichia coli (P<0.0001). In particular Pseudomonas spp. and E. coli were negatively correlated to PHC presence and positively correlated to CCA by both univariate and multivariate analysis.
CONCLUSIONS: Gram-negative bacteria have been linked to a tumour-associated inflammatory status. In the last 30 years, the analysis of mortality rate in Italy for PHC and GBC shows an increasing and a decreasing trend, respectively. Although this study targeted only 53 patients and does not reflect the frequency of diagnosis in a Southern Italian population, the decrease in GBC may raise the suggestion ofnon-adherence to a Mediterranean diet that may have become more prevalent in Southern Italy since the 1990s.
摘要：
目的：胆汁是一种富含肝胆脂质的无菌溶液，微生物定植定义了bactibilia的状况。在这项研究中,我们旨在评估胆汁微生物菌群及其与女性共病的潜在联系.
方法：我们对53名女性胆胰疾病患者进行了微生物学调查，我们使用MATLAB平台对数据进行了分析。
结果：我们发现，最常见的疾病与bactbilia相关是胰头癌（PHC）（P=0.0015），而最不常见的疾病是胆囊癌（GBC）（P=0.0002）。最常见的微生物是假单胞菌属。(P<0.0001)和大肠杆菌(P<0.0001)。特别是假单胞菌属。通过单变量和多变量分析，大肠杆菌与PHC的存在呈负相关，与CCA呈正相关。
结论：革兰氏阴性菌与肿瘤相关的炎症状态有关。在过去的30年里,意大利PHC和GBC的死亡率分析显示出上升和下降的趋势，分别。尽管这项研究仅针对53名患者，但并未反映出意大利南部人群的诊断频率，GBC的减少可能会提出不遵守地中海饮食的建议，自1990年代以来，地中海饮食在意大利南部变得更加普遍。
方法：我们对53名女性胆胰疾病患者进行了微生物学调查，我们使用MATLAB平台对数据进行了分析。
结果：我们发现，最常见的疾病与bactbilia相关是胰头癌（PHC）（P=0.0015），而最不常见的疾病是胆囊癌（GBC）（P=0.0002）。最常见的微生物是假单胞菌属。(P<0.0001)和大肠杆菌(P<0.0001)。特别是假单胞菌属。通过单变量和多变量分析，大肠杆菌与PHC的存在呈负相关，与CCA呈正相关。
结论：革兰氏阴性菌与肿瘤相关的炎症状态有关。在过去的30年里,意大利PHC和GBC的死亡率分析显示出上升和下降的趋势，分别。尽管这项研究仅针对53名患者，但并未反映出意大利南部人群的诊断频率，GBC的减少可能会提出不遵守地中海饮食的建议，自1990年代以来，地中海饮食在意大利南部变得更加普遍。
