Mesh : Adult Aptamers, Nucleotide / genetics metabolism therapeutic use Asthma / genetics immunology pathology therapy Child Chronic Disease DNA, Catalytic / genetics metabolism therapeutic use GATA3 Transcription Factor / antagonists & inhibitors genetics immunology Gene Expression Genetic Predisposition to Disease Genetic Therapy / methods Humans Interleukin-13 / antagonists & inhibitors genetics immunology Interleukin-4 / antagonists & inhibitors genetics immunology Oligonucleotides, Antisense / genetics metabolism therapeutic use Quality of Life RNA Interference RNA, Catalytic / genetics metabolism therapeutic use