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Abstract：
The purpose of this study was to determine whether metrics of brain tissue integrity derived from postmortem magnetic resonance imaging (MRI) are associated with late-life cognitive decline, independent of cerebral vessel disease. Using data from 554 older adults, we used voxelwise regression to identify regions where the postmortem MRI transverse relaxation rate constant R2 was associated with the rate of decline in global cognition. We then used linear mixed models to investigate the association between a composite R2 measure and cognitive decline, controlling for neuropathology including 3 indices of vessel disease: atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. This composite R2 measure was associated with the rate of decline (0.049 unit annually per R2 unit, p < 0.0001) and accounted for 6.1% of its variance, beyond contributions from vessel disease indices and other prominent age-related neuropathologies. Thus, postmortem brain R2 reflects disease processes underlying cognitive decline that are not captured by vessel disease indices or other standard neuropathologic indices and may provide a measure of brain tissue integrity that is complementary to histopathologic evaluation.
摘要：
这项研究的目的是确定从死后磁共振成像（MRI）得出的脑组织完整性指标是否与晚年认知能力下降有关。独立于脑血管疾病。使用554名老年人的数据，我们使用体素回归来确定死后MRI横向弛豫率常数R2与整体认知下降率相关的区域.然后，我们使用线性混合模型来研究复合R2度量与认知下降之间的关联，控制神经病理学，包括血管疾病的3个指标：动脉粥样硬化，动脉硬化，和脑淀粉样血管病.这一综合R2度量与下降率相关(每R2单位每年0.049单位，p<0.0001)，占其方差的6.1%，除了血管疾病指数和其他突出的年龄相关神经病理学的贡献。因此，尸检后脑R2反映了血管疾病指数或其他标准神经病理学指数未发现的认知减退的疾病过程,并且可以提供一种补充组织病理学评估的脑组织完整性的量度.
