Abstract:
Male-pattern hair loss (MPHL, androgenetic alopecia) is a slowly progressive form of alopecia which begins after puberty. In 2010, we published the first Japanese edition of guidelines for the diagnosis and treatment of MPHL. It achieved the original goal of providing physicians and patients in Japan with evidence-based information for choosing efficacious and safe therapy for MPHL. Subsequently, new therapeutic drugs and treatment methods have been developed, and women\'s perception of MPHL has undergone change and the term \"female-pattern hair loss (FPHL)\" is becoming more common internationally. Thus, here we report a revised version of the 2010 guidelines aimed at both MPHL and FPHL. In these guidelines, finasteride 1 mg daily, dutasteride 0.5 mg daily and topical 5% minoxidil twice daily for MPHL, and topical 1% minoxidil twice daily for FPHL, are recommended as the first-line treatments. Self-hair transplantation, irradiation by light-emitting diodes and low-level lasers, and topical application of adenosine for MPHL are recommended, whereas prosthetic hair transplantation and oral administration of minoxidil should not be performed. Oral administration of finasteride or dutasteride are contraindicated for FPHL. In addition, we have evaluated the effectiveness of topical application of carpronium chloride, t-flavanone, cytopurine, pentadecane and ketoconazole, and wearing a wig. Unapproved topical application of bimatoprost and latanoprost, and emerging hair regeneration treatments have also been addressed. We believe that the revised guidelines will improve further the diagnostic and treatment standards for MPHL add FPHL in Japan.
摘要:
男性型脱发(MPHL,雄激素性脱发)是一种缓慢进展的脱发形式,在青春期后开始。2010年,我们发布了第一本日本版的MPHL诊断和治疗指南。它实现了最初的目标,即为日本的医生和患者提供基于证据的信息,以选择有效和安全的MPHL疗法。随后,已经开发了新的治疗药物和治疗方法,女性对MPHL的看法发生了变化,“女性型脱发(FPHL)”一词在国际上变得越来越普遍。因此,在这里,我们报告了针对MPHL和FPHL的2010年指南的修订版。在这些准则中,非那雄胺每天1毫克,dutasteride0.5mg每日和外用5%米诺地尔每日两次用于MPHL,外用1%米诺地尔每天两次用于FPHL,被推荐为一线治疗。自体毛发移植,发光二极管和低能级激光器的照射,建议局部应用腺苷治疗MPHL,而假发移植和口服米诺地尔不应该进行。口服非那雄胺或度他雄胺对于FPHL是禁忌的。此外,我们已经评估了局部应用氯化碳素的有效性,t-黄烷酮,尿嘧啶,十五烷和酮康唑,戴着假发.未经批准的比马前列素和拉坦前列素的局部应用,和新兴的头发再生治疗也得到了解决。我们相信,修订后的指南将进一步提高日本MPHL和FPHL的诊断和治疗标准。