Abstract：
The aims of this study were to describe the clinical and radiologic features of 383 fibro-osseous lesions (FOLs) from an oral pathology reference service in Brazil and to compare the findings with previous studies. The hypothesis of the study was that the most common type of FOL would differ from other investigations.
We conducted a descriptive and retrospective study with review of the records of the clinical and biopsy services (1990 to 2015). All records of the patients included showed a definitive diagnosis of FOL. The primary outcome variable was the type of FOL, and the predictor variables were gender, age, ethnicity, location, and clinical and radiologic characteristics. Descriptive analyses and χ2 tests were performed. The P value was set at .05.
From the 27,998 records available, 383 showed FOLs, with 187 (48.8%) being cemento-osseous dysplasias (CODs), 103 (26.9%) being fibrous dysplasias (FDs), and 93 (24.3%) being ossifying fibromas (OFs). The mean age of the patients was 38.5 ± 17.5 years. CODs presented a predilection for female gender (n = 314, 82.0%), African descent (n = 134, 71.6%), and the mandible (n = 248, 64.6%). The most common radiologic feature was a mixed radiolucent-radiopaque image (n = 149, 51.7%). FDs and OFs were commonly diagnosed during the first and second decades of life (P < .001), whereas CODs were more frequently diagnosed beyond the third decade (P < .001). Secondary osteomyelitis was more significantly observed in CODs (P < .001) than in FDs and OFs. Swelling was more frequently reported for FDs and OFs than for CODs (P < .001).
CODs were the most frequently observed FOLs in this Brazilian population. Female patients, patients of African descent, and patients with mandibular localization were most commonly affected by these conditions. The most common type of FOL differed from that in similar case reports or series from various geographic locations. It is believed that the data source (clinical and/or biopsy services) can directly influence the outcome.
We conducted a descriptive and retrospective study with review of the records of the clinical and biopsy services (1990 to 2015). All records of the patients included showed a definitive diagnosis of FOL. The primary outcome variable was the type of FOL, and the predictor variables were gender, age, ethnicity, location, and clinical and radiologic characteristics. Descriptive analyses and χ2 tests were performed. The P value was set at .05.
From the 27,998 records available, 383 showed FOLs, with 187 (48.8%) being cemento-osseous dysplasias (CODs), 103 (26.9%) being fibrous dysplasias (FDs), and 93 (24.3%) being ossifying fibromas (OFs). The mean age of the patients was 38.5 ± 17.5 years. CODs presented a predilection for female gender (n = 314, 82.0%), African descent (n = 134, 71.6%), and the mandible (n = 248, 64.6%). The most common radiologic feature was a mixed radiolucent-radiopaque image (n = 149, 51.7%). FDs and OFs were commonly diagnosed during the first and second decades of life (P < .001), whereas CODs were more frequently diagnosed beyond the third decade (P < .001). Secondary osteomyelitis was more significantly observed in CODs (P < .001) than in FDs and OFs. Swelling was more frequently reported for FDs and OFs than for CODs (P < .001).
CODs were the most frequently observed FOLs in this Brazilian population. Female patients, patients of African descent, and patients with mandibular localization were most commonly affected by these conditions. The most common type of FOL differed from that in similar case reports or series from various geographic locations. It is believed that the data source (clinical and/or biopsy services) can directly influence the outcome.
摘要：
这项研究的目的是描述来自巴西口腔病理学参考服务的383个纤维骨病变（FOL）的临床和放射学特征，并将这些发现与以前的研究进行比较。该研究的假设是最常见的FOL类型与其他研究不同。
我们进行了一项描述性和回顾性研究，回顾了临床和活检服务的记录（1990年至2015年）。包括的所有患者记录均显示明确的FOL诊断。主要结果变量是FOL的类型，预测变量是性别，年龄,种族,location,以及临床和放射学特征。进行描述性分析和χ2检验。P值设定为0.05。
从现有的27,998条记录中，383显示FOLs，187例（48.8％）为骨水泥发育不良（COD），103（26.9%）为纤维状发育不良（FD），骨化纤维瘤（OFs）93例（24.3%）。患者的平均年龄为38.5±17.5岁。CODs对女性性别有偏好(n=314，82.0%)，非洲裔（n=134，71.6%），和下颌骨（n=248，64.6%）。最常见的放射学特征是不透射线的混合射线图像（n=149，51.7％）。FD和OF通常在生命的第一个和第二个十年被诊断出来（P<.001），而CODs在第三个十年后被诊断的频率更高(P<.001)。继发性骨髓炎在CODs（P<.001）中比在FD和OFs中更明显。FDs和OFs的肿胀报告频率高于CODs(P<.001)。
CODs是巴西人群中最常见的FOLs。女性患者,非洲裔患者，下颌定位的患者最常受到这些疾病的影响。最常见的FOL类型与来自不同地理位置的类似病例报告或系列中的FOL不同。相信数据源(临床和/或活检服务)可以直接影响结果。
我们进行了一项描述性和回顾性研究，回顾了临床和活检服务的记录（1990年至2015年）。包括的所有患者记录均显示明确的FOL诊断。主要结果变量是FOL的类型，预测变量是性别，年龄,种族,location,以及临床和放射学特征。进行描述性分析和χ2检验。P值设定为0.05。
从现有的27,998条记录中，383显示FOLs，187例（48.8％）为骨水泥发育不良（COD），103（26.9%）为纤维状发育不良（FD），骨化纤维瘤（OFs）93例（24.3%）。患者的平均年龄为38.5±17.5岁。CODs对女性性别有偏好(n=314，82.0%)，非洲裔（n=134，71.6%），和下颌骨（n=248，64.6%）。最常见的放射学特征是不透射线的混合射线图像（n=149，51.7％）。FD和OF通常在生命的第一个和第二个十年被诊断出来（P<.001），而CODs在第三个十年后被诊断的频率更高(P<.001)。继发性骨髓炎在CODs（P<.001）中比在FD和OFs中更明显。FDs和OFs的肿胀报告频率高于CODs(P<.001)。
CODs是巴西人群中最常见的FOLs。女性患者,非洲裔患者，下颌定位的患者最常受到这些疾病的影响。最常见的FOL类型与来自不同地理位置的类似病例报告或系列中的FOL不同。相信数据源(临床和/或活检服务)可以直接影响结果。
