Abstract：
Amelanotic melanoma (AM) is a rare form of melanoma which lacks visible pigment. Due to the achromic manifestation of this atypical cutaneous malignancy, it has been difficult to establish clinical criteria for diagnosis. Thus, AM often progresses into an invasive disease due to delayed diagnosis. In this report, we describe the case of a 72-year-old Caucasian woman who had been diagnosed with AM after 3 years of failed treatments for what presented as a periorbital dermatitis. Her Clark\'s level 4, 1.30 mm thick melanoma required nine surgeries for successful resection and reconstruction. This case exemplifies the diagnostic pitfall of AM and the need for new criteria for early detection and management.
摘要：
无色素性黑色素瘤（AM）是一种罕见的黑色素瘤，缺乏可见色素。由于这种不典型的皮肤恶性肿瘤的消色表现，很难建立临床诊断标准。因此，由于诊断延迟，AM通常会发展为侵袭性疾病。在这份报告中,我们描述了一例72岁的白种人女性,该女性在3年治疗失败后被诊断为AM,表现为眶周皮炎.她的Clark的4级，1.30毫米厚的黑色素瘤需要9次手术才能成功切除和重建。此案例说明了AM的诊断缺陷以及对早期检测和管理的新标准的需求。
