关键词: Endonasal surgery Endoscopic nasal surgery Endoscopic turbinoplasty FEES, Functional Endoscopic Endonasal Surgery Haemostasis PuraStat RADA, short peptide made of 4 amino acids (Arginine-Alanine-Aspartic acid-Alanine) repeated 4 times

来  源:   DOI:10.1016/j.ijscr.2017.11.024   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
UNASSIGNED: Recently, a novel purely synthetic topical haemostatic agent (PuraStat®) has been proposed in surgery based on the self-assembling tendency of some repeating peptide sequences. This transparent, ready to use hydrogel appears suitable for use in FEES with low rates of post-operative re-bleeding and adhesion formation.A first series of 60 patients experiencing endonasal powered turbinoplasty across various hospitals in Sydney using PuraStat® was observed for postoperative re-bleeding and adhesion formation.
UNASSIGNED: In all 60 patients, no post-operative re-bleeding was observed, while healing went well in absence of adhesion formation. Effective haemostasis with PuraStat® is well documented in other surgical fields, but its use in FEES and adhesion prevention is relatively novel.
UNASSIGNED: Synthetic self-assembling peptides appear to be indicated in this area. Further studies are needed to confirm their potential for adhesion prevention.
摘要:
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