{Reference Type}: Journal Article
{Title}: A novel haemostatic agent based on self-assembling peptides in the setting of nasal endoscopic surgery, a case series.
{Author}: Lee MF;Ma Z;Ananda A;
{Journal}: Int J Surg Case Rep
{Volume}: 41
{Issue}: 0
{Year}: 2017
暂无{DOI}: 10.1016/j.ijscr.2017.11.024
{Abstract}: <B>UNASSIGNED: </B>Recently, a novel purely synthetic topical haemostatic agent (PuraStat®) has been proposed in surgery based on the self-assembling tendency of some repeating peptide sequences. This transparent, ready to use hydrogel appears suitable for use in FEES with low rates of post-operative re-bleeding and adhesion formation.A first series of 60 patients experiencing endonasal powered turbinoplasty across various hospitals in Sydney using PuraStat® was observed for postoperative re-bleeding and adhesion formation.<BR><B>UNASSIGNED: </B>In all 60 patients, no post-operative re-bleeding was observed, while healing went well in absence of adhesion formation. Effective haemostasis with PuraStat® is well documented in other surgical fields, but its use in FEES and adhesion prevention is relatively novel.<BR><B>UNASSIGNED: </B>Synthetic self-assembling peptides appear to be indicated in this area. Further studies are needed to confirm their potential for adhesion prevention.