Mesh : Animals Base Composition Base Sequence Humans Introns RNA Splicing RNA, Fungal / genetics RNA, Messenger / genetics metabolism Ribonucleoproteins / genetics metabolism Ribonucleoproteins, Small Nuclear Saccharomyces cerevisiae / genetics

来  源:   DOI:10.1038/325673a0   PDF(Sci-hub)

Abstract:
A small set of distinctive short RNA molecules are found in the nuclei of all higher eukaryotic cells and yeast, in protein complexes known as \'small nuclear ribonucleoprotein particles\', or snRNPs. Recent work has confirmed early suggestions that these particles form part of the machinery by which primary RNA transcripts are processed to their mature, functional form. In particular, snRNPs have been shown to be an integral part of the \'spliceosome\', a multi-component complex involved in the removal of intron sequences from the coding regions of messenger RNA precursors.
摘要:
在所有高等真核细胞和酵母的细胞核中发现了一组独特的短RNA分子,在被称为“小核核糖核蛋白颗粒”的蛋白质复合物中,或snRNP。最近的工作证实了早期的建议,即这些颗粒构成了初级RNA转录本加工成熟的机制的一部分,功能形式。特别是,snRNP已被证明是“剪接体”的组成部分,涉及从信使RNA前体的编码区去除内含子序列的多组分复合物。
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