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Abstract：
Primary cutaneous aspergillosis is a rare, life-threatening fungal infection in premature infants. We report a case of primary cutaneous aspergillosis caused by Aspergillus tamarii in an extremely low birthweight infant. The infant was delivered by cesarean section with complications from an intrauterine infection, brain intraventricular hemorrhage, tension pneumothorax and cardiac tamponade. On the 12th day of life, he developed erythematous maceration with erosion on his back. Septate hyphae were detected on two occasions from specimens of the skin lesion. The manifestations of the colony and slide culture showed the characteristics of A. tamarii. The nucleotide sequences of internal transcribed spacer regions of the ribosomal RNA gene, partial sequences of β-tubulin and calmodulin gene were compatible with those of A. tamarii. Of the known Aspergillus species, Aspergillus fumigatus and Aspergillus flavus have been reported in previous studies as the major causative agents in primary cutaneous aspergillosis, whereas human infection by A. tamarii is rare. We consider that A. tamarii is important as an unusual opportunistic human pathogen among premature infants.
摘要：
原发性皮肤曲霉病是一种罕见的，早产儿中威胁生命的真菌感染。我们报告了一例极低出生体重婴儿中由tamarii曲霉引起的原发性皮肤曲霉病。该婴儿是通过剖宫产分娩的，患有宫内感染的并发症，脑脑室内出血，张力性气胸和心脏填塞。在生命的第12天，他的背部出现红斑性浸蚀。两次从皮肤病变标本中检测到间隔状菌丝。菌落和载玻片培养的表现表现了A.tamarii的特征。核糖体RNA基因的内部转录间隔区的核苷酸序列，β-微管蛋白和钙调蛋白基因的部分序列与tamarii的部分序列一致。在已知的曲霉种类中，在先前的研究中已经报道了烟曲霉和黄曲霉是原发性皮肤曲霉病的主要病原体，而人类感染A.tamarii是罕见的。我们认为，tamarii是早产儿中一种不寻常的机会性人类病原体。
