关键词: ADCY3 MC4R cAMP diabetes genetic mutations obesity

Mesh : Dancing Genotype Humans Mutation Obesity Obesity, Morbid

来  源:   DOI:10.1016/j.tem.2018.02.004

Abstract:
The genetic etiology for obesity-related traits remains elusive. Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of obesity. These findings provide new information on obesity etiology and suggest potential anti-obesity therapeutic strategies.
摘要:
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