Abstract：
Proton beam therapy (PBT) has been increasingly used in a variety of cancers due to its excellent physical properties and superior dosimetric parameters. PBT may improve patient survival by improving the local tumor treatment rate while reducing injury to normal organs, which may result in fewer radiation-induced adverse effects. However, the significant cost of establishing and maintaining proton facilities cannot be overlooked. In addition, there has been significant controversy regarding routine application of this treatment in certain types of cancer. The challenges of PBT in the future mainly include the lack of basic clinical trials, unclear biological effects, immature imaging technology and miniaturization of imaging guidance. Overcoming these limitations may promote the rapid development of PBT. We herein provide an overview of the existing literature on the efficacy and toxicity of common oncological applications of proton beam therapy.
摘要：
质子束疗法(PBT)由于其优异的物理性质和优异的剂量学参数而越来越多地用于各种癌症。PBT可以通过提高局部肿瘤治疗率，同时减少对正常器官的损伤来提高患者的生存率。这可能导致较少的辐射诱导的不利影响。然而,建立和维护质子设施的巨大成本不容忽视。此外,在某些类型的癌症中常规应用这种治疗方法一直存在重大争议.未来PBT面临的挑战主要包括缺乏基础临床试验,生物效应不明确,成像技术的不成熟和成像指导的小型化。克服这些局限性可能会促进PBT的快速发展。我们在此提供了关于质子束治疗的常见肿瘤应用的功效和毒性的现有文献的概述。
