多功能缩氨基硫脲和解构类似物作为研究金属螯合作用的策略 ,Sigma - 2 ( σ 2 ) 受体和 P - gp 蛋白在细胞毒性作用中的作用 : 胰腺肿瘤的体外和体内活性。
关键词: Mithocondrial superoxide Multifunctional compounds Pancreatic cancer Sigma-2 receptors Thiosemicarbazones
Mesh : ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors metabolism Animals Antineoplastic Agents / chemical synthesis chemistry pharmacology Cell Death / drug effects Cell Proliferation / drug effects Cell Survival / drug effects Chelating Agents / chemical synthesis chemistry pharmacology Disease Models, Animal Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Humans Mice Mice, Inbred C57BL Molecular Structure Neoplasms, Experimental / drug therapy metabolism pathology Pancreatic Neoplasms / drug therapy metabolism pathology Receptors, sigma / antagonists & inhibitors metabolism Structure-Activity Relationship Thiosemicarbazones / chemical synthesis chemistry pharmacology
来 源:
DOI:10.1016/j.ejmech.2017.12.024
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