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Abstract：
Colorectal cancer is one of the most common malignant tumours. Competitive endogenous RNA (ceRNA) networks have been hypothesized, in which various RNAs regulate each other\'s expression using microRNA response elements (MREs). Recent evidence has highlighted the crucial regulatory roles of ceRNA networks in colorectal cancer. In this review, we summarize the present research methods as well as the currently known ceRNA competitors and targets in colorectal cancer. In addition, we discuss the significance of ceRNA and shortcomings of current studies of colorectal cancer.
摘要：
结直肠癌是最常见的恶性肿瘤之一。竞争性内源性RNA(ceRNA)网络已经被假设，其中各种RNA使用microRNA反应元件(MRE)调节彼此的表达。最近的证据强调了ceRNA网络在结直肠癌中的重要调节作用。在这次审查中,我们总结了目前结直肠癌的研究方法以及目前已知的ceRNA竞争因子和靶点。此外,我们讨论了ceRNA的意义和目前结直肠癌研究的不足。
