Growth Restriction, Osteopenia, Placental Massive Perivillous Fibrin Deposition With (or Without) Intervillous Histiocytes and Renal Tubular Dysgenesis-An Emerging Complex.

• 影响指数: 2.266
• 发表时间: Jan-Feb 2018
• 来源期刊: Pediatr Dev Pathol
• DOI: 10.1177/1093526617697061
• PMID: 29187034
• 文章类型: Case Reports
• 中科院分区: Q4
• 方向: 医学
• 作者列表: Abdulghani S,Moretti F,Nikkels PG,Khung-Savatovsky S,Hurteau-Miller J,Grynspan D

关键词: chronic intervillosistis; fetal; intrauterine growth restriction; massive perivillous fibrin; placenta; renal tubular dysgenesis

Mesh: Abortion, Eugenic; Adult; Bone Diseases, Metabolic / diagnosis pathology; Female; Fetal Growth Retardation / diagnosis pathology; Humans; Kidney Tubules, Proximal / abnormalities pathology; Male; Placenta Diseases / diagnosis pathology; Pregnancy; Syndrome; Urogenital Abnormalities / diagnosis pathology

Abstract

We describe a case of a pregnancy complicated by early onset asymmetric growth restriction with anhydramnios with termination occurring at 21 weeks. Fetal autopsy showed demineralization of bones and renal tubular dysgenesis. Placental pathology showed features of massive perivillous fibrin deposition and chronic histiocytic intervillositis. We review prior documentation of this association and briefly discuss potential pathogenesis.