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Abstract：
It is common to observe the persistence of extra-axial collections after craniotomies. Most of these disappear in weeks or months but some remain. The onset of focal symptoms or the growth of these persistent collections months or years after surgery may indicate the presence of a chronic and latent infection by germs of low virulence such as Propionibacterium acnes (P. acnes).
We present two clinical cases with persistent extra-axial collections, which required surgery years after diagnosis, in which P. acnes was isolated as an aetiological agent and we reviewed the literature published in this regard.
These are two patients who, following surgical procedures (decompressive craniectomy for severe TBI and craniotomy for right parietal meningioma) and extra-axial collections were kept, which were monitored over time and then were infected and required emergency evacuation. In these collections P. acnes grew as a causal agent and required targeted antibiotics.
We must consider P. acnes as an infectious agent of post-surgical collections of long evolution. Atypical presentation and radiological changes may be helpful in diagnosis.
We present two clinical cases with persistent extra-axial collections, which required surgery years after diagnosis, in which P. acnes was isolated as an aetiological agent and we reviewed the literature published in this regard.
These are two patients who, following surgical procedures (decompressive craniectomy for severe TBI and craniotomy for right parietal meningioma) and extra-axial collections were kept, which were monitored over time and then were infected and required emergency evacuation. In these collections P. acnes grew as a causal agent and required targeted antibiotics.
We must consider P. acnes as an infectious agent of post-surgical collections of long evolution. Atypical presentation and radiological changes may be helpful in diagnosis.
摘要：
通常观察开颅术后轴外集合的持久性。其中大多数在几周或几个月内消失，但有些仍然存在。手术后数月或数年出现局灶性症状或这些持续收集物的生长可能表明存在低毒力细菌的慢性和潜伏感染，例如痤疮丙酸杆菌（P.痤疮）。
我们介绍了两个持续轴外集合的临床病例，诊断后需要手术，其中痤疮丙酸杆菌被分离为病原体，我们回顾了在这方面发表的文献。
这是两个病人,在外科手术（严重TBI的去骨瓣减压术和右顶叶脑膜瘤的开颅术）和轴外收集后，随着时间的推移进行监测，然后被感染，需要紧急疏散。在这些集合中,痤疮丙酸杆菌作为病原体生长并且需要靶向抗生素。
我们必须考虑痤疮丙酸杆菌是长期进化的术后集合的感染因子。非典型表现和放射学变化可能有助于诊断。
我们介绍了两个持续轴外集合的临床病例，诊断后需要手术，其中痤疮丙酸杆菌被分离为病原体，我们回顾了在这方面发表的文献。
这是两个病人,在外科手术（严重TBI的去骨瓣减压术和右顶叶脑膜瘤的开颅术）和轴外收集后，随着时间的推移进行监测，然后被感染，需要紧急疏散。在这些集合中,痤疮丙酸杆菌作为病原体生长并且需要靶向抗生素。
我们必须考虑痤疮丙酸杆菌是长期进化的术后集合的感染因子。非典型表现和放射学变化可能有助于诊断。
