Abstract：
Papillary thyroid carcinoma is the most common thyroid malignancy and it is usually associated with a good prognosis. However, recurrence, metastases, and cancer death may occur in 10 to 15% of patients with more aggressive types of papillary thyroid carcinoma, such as tall cell, columnar cell, solid variant, or the more recently described hobnail variant of papillary thyroid carcinoma. Papillary thyroid carcinoma with a prominent hobnail pattern is a moderately differentiated papillary thyroid carcinoma variant with aggressive clinical behavior and significant mortality. The hobnail variant of papillary thyroid carcinoma shows prominent hobnail features, which have also been referred to as micropapillary. The typical hobnail/micropapillary morphological features show loss of cellular polarity/cohesiveness and support an epithelial-mesenchymal transition as a possible mechanism of metastasis. BRAF p.V600E is the most common mutation in papillary thyroid carcinoma, including the hobnail variant; recent and continuing studies are focused on defining other molecular anomalies that may be useful for prognostic stratification and may provide therapeutic targets.
摘要：
甲状腺乳头状癌是最常见的甲状腺恶性肿瘤，通常预后良好。然而,复发,转移,癌症死亡可能发生在10％至15％的更具侵袭性的甲状腺乳头状癌类型的患者中，比如高大的细胞，柱状细胞,固体变体，或最近描述的甲状腺乳头状癌的hobnail变体。具有突出的hobnail模式的甲状腺乳头状癌是一种中分化的甲状腺乳头状癌变体，具有侵袭性的临床行为和显着的死亡率。甲状腺乳头状癌的hobnail变体显示出突出的hobnail特征，也被称为微乳头。典型的hobnail/微乳头形态特征显示细胞极性/粘结性丧失，并支持上皮-间质转化作为转移的可能机制。BRAFp.V600E是甲状腺乳头状癌中最常见的突变,包括hobnail变异;最近和持续的研究集中在定义其他可能对预后分层有用并可能提供治疗靶点的分子异常。
